Results 161 to 170 of about 2,143,309 (303)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

DNA barcoding, forensics, and application of DNA chip technology

, 2010
Among the 1,121 recognized fish species in Korean waters, approximately 9% (12 Elasmobranchii and 88 Actinopterygii species) have been barcoded with regards to the COI sequences. The DNA barcodes have been used for investigation of correctness in species
이유철, 이강현, 김고은, 김성, 강미혜, Habib, 배세진, Seung Yong Hwang, 정다금, 오지나, 이윤호   +10 more
core   +1 more source

HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes. [PDF]

Proc Natl Acad Sci U S A, 2020
Marshall JL, Doughty BR, Subramanian V, Guckelberger P, Wang Q, Chen LM, Rodriques SG, Zhang K, Fulco CP, Nasser J, Grinkevich EJ, Noel T, Mangiameli S, Bergman DT, Greka A, Lander ES, Chen F, Engreitz JM.   +17 more
europepmc   +1 more source

Probing the brain with DNA chips [PDF]

Nature Neuroscience, 1999
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Detection of Down syndrome by in situ hybridization with chromosome 21 specific DNA probes [PDF]

, 1990
Cremer, Thomas, Patterson, David, Lichter, Peter, Jauch, Anna, Ward, D. C.   +4 more
core   +1 more source

Utilization of specific DNA-probes for the rapid detection of Campylobacter spp. in meat by using an OLED-based reader

, 2015
The European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC) report campylobacteriosis was the most commonly reported zoonosis in 2012.
MANZANO, Marisa, Patrizia Melpignano, COMI, Giuseppe, IACUMIN, Lucilla, Francesca Cecchini   +4 more
core   +1 more source

"AND" or "OR" logic operations of DNA probes: Fluorescent detection and discrimination of ovarian cancer cells via dual-microRNA in complex environments. [PDF]

Mater Today Bio
Wang G, Li Y, Liu S, Li J, Yao M, Cheng J, Chen T, Zhang J, Gao F, Du W, Hua L.   +10 more
europepmc   +1 more source