Results 181 to 190 of about 792,120 (349)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes. [PDF]

Proc Natl Acad Sci U S A, 2020
Marshall JL, Doughty BR, Subramanian V, Guckelberger P, Wang Q, Chen LM, Rodriques SG, Zhang K, Fulco CP, Nasser J, Grinkevich EJ, Noel T, Mangiameli S, Bergman DT, Greka A, Lander ES, Chen F, Engreitz JM.   +17 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

"AND" or "OR" logic operations of DNA probes: Fluorescent detection and discrimination of ovarian cancer cells via dual-microRNA in complex environments. [PDF]

Mater Today Bio
Wang G, Li Y, Liu S, Li J, Yao M, Cheng J, Chen T, Zhang J, Gao F, Du W, Hua L.   +10 more
europepmc   +1 more source

Direct Detection and Discrimination of Nucleotide Polymorphisms Using Anthraquinone Labeled DNA Probes. [PDF]

Front Chem, 2020
Goodchild SA, Gao R, Shenton DP, McIntosh AJS, Brown T, Bartlett PN.   +5 more
europepmc   +1 more source

A Bi-Terminal Protein Ligation Strategy To Probe Chromatin Structure During Dna Damage - Fig. 4E

, 2018
Sinan Kilic, Iuliia Boichenko, Carolin C. Lechner, Beat Fierz   +3 more
openalex   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

DNA and RNA editing without sequence limitation using the flap endonuclease 1 guided by hairpin DNA probes. [PDF]

Nucleic Acids Res, 2020
Tian K, Guo Y, Zou B, Wang L, Zhang Y, Qi Z, Zhou J, Wang X, Zhou G, Wei L, Xu S.   +10 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A Lactobacillus helveticus -Specific DNA Probe Detects Restriction Fragment Length Polymorphisms in This Species [PDF]

, 1992
Clara G. de los Reyes‐Gavilán, G. K. Y. Limsowtin, Patrick Tailliez, Laurent Séchaud, Jean-Pierre Accolas   +4 more
openalex   +1 more source