Results 241 to 250 of about 3,725,761 (393)

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

The DNA Repair Component EEPD1 Regulates Actin Polymerization. [PDF]

Biol Cell
Hromas R, Kirby A, Carrillo A, Jasiwal A, Kong K, Tran MT, Arris D, Williamson EA.   +7 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair. [PDF]

Sci Rep
Sun L, Xu Z, Zhang X, Du X, Li G, Guo Y.
europepmc   +1 more source

A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS [PDF]

, 1977
Thomas M. Koval, Ronald W. Hart, Willard C. Myser, W.F. Hink   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

βTrCP facilitates MRN complex localization on chromatin to enhance DNA repair. [PDF]

Commun Biol
Belmonte-Fernández A, Herrero-Ruíz J, Sáez C, Japón MÁ, Mora-Santos M, Romero F.   +5 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Telomere Maintenance and DNA Repair: A Bidirectional Relationship in Cancer Biology and Therapy. [PDF]

Cancers (Basel)
Rembiałkowska N, Sędzik M, Kisielewska M, Łuniewska W, Sebastianka K, Molik K, Skinderowicz K, Kuźnicki J, Tunikowska J, Kulbacka J.   +9 more
europepmc   +1 more source

Mutagenicity of industrial compounds. VII. Styrene and styrene oxide: II. Point mutations, chromosome aberrations and DNA repair induction analyses.

, 1978
N. Loprieno, Silvano Presciuttini, Isabella Sbrana, G Stretti, Laura Zaccaro, Alberto Abbondandolo, Stefano Bonatti, R. Fiorio, A. Mazzaccaro   +8 more
openalex   +2 more sources