Results 241 to 250 of about 1,028,456 (338)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ. [PDF]

Nat Commun
Martin PR, Nieminuszczy J, Kozik Z, Jakub N, Kowalski S, Lecot M, Vorhauser J, Lane KA, Kanellou A, Mansfeld J, Pearl LH, Oliver AW, Downs JA, Choudhary JS, Day M, Niedzwiedz W.   +15 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms. [PDF]

Blood Cancer J
Meyer R, Rodriguez MJ, Caduc M, Kricheldorf K, Begemann M, Kraft F, Spier I, Dey D, Güzel N, Becker K, Baumeister J, S de Toledo MA, Isfort S, Germing U, Aretz S, Brümmendorf TH, Kurth I, Elbracht M, Teichmann LL, Koschmieder S.   +19 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair. [PDF]

Nat Commun
Jiang Y, Przybilla M, Bakker L, Jacobs FC, Mckeon D, van der Sluijs R, Sato K, Wezenbeek J, van Strien J, Willems J, Verkennis AEE, Barnett J, Ortega AB, Abascal F, Villalta PW, Knipscheer P, Martincorena I, Balbo S, Garaycoechea J.   +18 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

LIG1 overexpression enhances DNA repair and immune escape leading to poor prognosis in osteosarcoma. [PDF]

Eur J Med Res
Fu W, Tang G, Tang Y, Yan P, Wang Q.
europepmc   +1 more source

IGFBP2 Is Overexpressed by Pediatric Malignant Astrocytomas and Induces the Repair Enzyme DNA-PK

, 2008
Oren J. Becher, Katia M. Peterson, Soumen Khatua, Maria Rita Santi, Tobey J. MacDonald   +4 more
openalex   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source