Results 121 to 130 of about 1,048,189 (263)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication
Molecular Oncology, 2016 DNA replication control is a key process in maintaining genomic integrity. Monitoring DNA replication initiation is particularly important as it needs to be coordinated with other cellular events and should occur only once per cell cycle. Crucial players
Santiago Hernández-Pérez +7 more
doaj +1 more source
Multiple C-Terminal Tails within a Single \u3cem\u3eE. coli\u3c/em\u3e SSB Homotetramer Coordinate DNA Replication and Repair [PDF]
, 2013 Escherichia coli single-stranded DNA binding protein (SSB) plays essential roles in DNA replication, recombination and repair. SSB functions as a homotetramer with each subunit possessing a DNA binding domain (OB-fold) and an intrinsically disordered C ...
Antony, Edwin +7 more
core +1 more source
DNA polymerase η is a substrate for calpain: A possible mechanism for pol η retention in UV induced replication foci [PDF]
, 2021 Jo-Ann Nettersheim +3 more
openalex +1 more source
CellsThe regulated formation and resolution of R-loops is a natural process in physiological gene expression. Defects in R-loop metabolism can lead to DNA replication stress, which is associated with a variety of diseases and, ultimately, with cancer.
Agnes Fütterer +4 more
doaj +1 more source
Nature Communications, 2016 In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork ...
Akshay K. Ahuja +10 more
doaj +1 more source
Limiting DNA replication to once and only once [PDF]
, 2000 Erik Boye +2 more
openalex +1 more source
Cellular and Molecular Life Sciences (CMLS), 1999 Geminiviruses are DNA viruses which infect plants. They have a small genome and encode only a few proteins. Therefore, their DNA replication cycle relies largely on the use of cellular DNA replication proteins. The strategy used by geminiviruses to replicate their single-stranded DNA (ssDNA) genome consists of a first stage of conversion of ssDNA into ...
openaire +3 more sources
Human Parvovirus B19 Infection Causes Cell Cycle Arrest of Human Erythroid Progenitors at Late S Phase That Favors Viral DNA Replication [PDF]
, 2013 Yong Luo +3 more
openalex +1 more source
Poxvirus DNA Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins for DNA replication and gene expression. Hairpin ends link the two strands of the linear, double-stranded DNA genome. Viral proteins involved in DNA synthesis include a 117-kDa polymerase, a helicase-primase, a uracil DNA glycosylase, a processivity factor, a ...
openaire +2 more sources