Results 311 to 320 of about 3,431,424 (346)
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Frontiers in Bioscience, 2004
The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM complex acts as a replicative helicase in eukaryotes.
Hideo Nishitani, Zoi Lygerou
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The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM complex acts as a replicative helicase in eukaryotes.
Hideo Nishitani, Zoi Lygerou
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Annual Review of Biochemistry, 1992
PERSPECTIVES AND SUMMARY ..... 673 INTRODUCTION TO REPLICATION OPERATIONS 674 ELONGATION..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 677 The DNA Polymerase Complexes 677 Primosomes .. . .... . ... .. . ..... . ...... . . ...... ... . . . ....... ... . .....
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PERSPECTIVES AND SUMMARY ..... 673 INTRODUCTION TO REPLICATION OPERATIONS 674 ELONGATION..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 677 The DNA Polymerase Complexes 677 Primosomes .. . .... . ... .. . ..... . ...... . . ...... ... . . . ....... ... . .....
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DNA replication in thermophiles
Biochemical Society Transactions, 2004DNA replication enzymes in the thermophilic Archaea have previously attracted attention due to their obvious use in methods such as PCR. The proofreading ability of the Pyrococcus furiosus DNA polymerase has resulted in a commercially successful product (Pfu polymerase).
James P. J. Chong +2 more
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On the mechanism of DNA replication
Journal of Theoretical Biology, 1965Abstract A mechanism of DNA replication is proposed which involves a bifunctional replicase enzyme. Evidence is cited indicating that the major groove of the DNA helix represents the site of its replication. Base pairing and synthesis of single strands is pictured as occurring simultaneously on opposing sides of the groove, thus involving bases which
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Physical Review Letters, 2010
We introduce a rate-equation formalism to study DNA replication kinetics in the presence of defects resulting from DNA damage and find a crossover between two regimes: a normal regime, where the influence of defects is local, and an initiation-limited regime.
Michel G. Gauthier +2 more
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We introduce a rate-equation formalism to study DNA replication kinetics in the presence of defects resulting from DNA damage and find a crossover between two regimes: a normal regime, where the influence of defects is local, and an initiation-limited regime.
Michel G. Gauthier +2 more
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Papillomavirus DNA Replication
2003Papillomavirus genomes replicate and are maintained as stable extrachromosomal plasmid DNA (episomes) in many cell lines (reviewed in ref. 1). This process requires the viral E1 and E2 proteins and the origin of replication (2,3). The minimal origin of replication consists of an E1 binding site, an E2 binding site, and an AT rich region that probably ...
Maureen C. Ferran, Alison A. McBride
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The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
Nature reviews. Molecular cell biology, 2020Matteo Berti, D. Cortez, M. Lopes
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1986
We have explored various strategies for exploiting the yeast genetic and biochemical system for understanding DNA replication. Because of the long time that has intervened between the isolation of random replication mutants of yeast and the identification of the gene products affected, an alternative approach to elucidating the molecular basis of ...
Martin E. Budd +6 more
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We have explored various strategies for exploiting the yeast genetic and biochemical system for understanding DNA replication. Because of the long time that has intervened between the isolation of random replication mutants of yeast and the identification of the gene products affected, an alternative approach to elucidating the molecular basis of ...
Martin E. Budd +6 more
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Journal of Theoretical Biology, 1972
Abstract The single postulate that proteins called π exist which recognize specific sequences (π sequences) in DNA and there cause the appropriate DNA polymerase to initiate synthesis of a polydeoxynucleotide chain provides an explanation of all the experimental observations relevant to DNA replication.
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Abstract The single postulate that proteins called π exist which recognize specific sequences (π sequences) in DNA and there cause the appropriate DNA polymerase to initiate synthesis of a polydeoxynucleotide chain provides an explanation of all the experimental observations relevant to DNA replication.
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1980
When new DNA molecules are synthesised, the information contained in the parental molecule is passed on with very great accuracy to the daughter molecules. The basic principle on which such accurate copying occurs is suggested by the double-helical structure of DNA; each strand serves as a template for the synthesis of a complementary strand, thus ...
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When new DNA molecules are synthesised, the information contained in the parental molecule is passed on with very great accuracy to the daughter molecules. The basic principle on which such accurate copying occurs is suggested by the double-helical structure of DNA; each strand serves as a template for the synthesis of a complementary strand, thus ...
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