Results 51 to 60 of about 910,557 (358)
Transcription-mediated replication hindrance: a major driver of genome instability [PDF]
, 2019 Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops.
Aguilera López, Andrés +1 more
core +1 more source
Molecules, 2021 This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We
Olalla Barreiro-Costa +11 more
doaj +1 more source
Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability [PDF]
, 2015 Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA
Anna L. Chambers +5 more
core +2 more sources
Ctf4 organizes sister replisomes and Pol α into a replication factory
eLife, 2019 The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase.
Zuanning Yuan +8 more
doaj +1 more source
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
Nature CommunicationsThe eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre ...
Sarah V. Faull +11 more
doaj +1 more source
DNAReplication: a database of information and resources for the eukaryotic DNA replication community [PDF]
, 2008 DNAReplication (at http://www.dnareplication.net) has been set up as a freely available single resource to facilitate access to information on eukaryotic DNA replication.
Forsburg +7 more
core +3 more sources
Evaluating the origin and spread of spotted lanternfly (Lycorma delicatula) in Japan
Population Ecology, EarlyView.The invasive spotted lanternfly (Lycorma delicatula) is native to China and is a serious economic pest in the Republic of Korea and the United States, though it is not considered a pest in Japan. We established a distribution map of L. delicatula in Japan through a comprehensive review of published literature and citizen science reports and analyzed ...
Matthew T. Kamiyama +5 more
wiley +1 more source
Nature CommunicationsHuman DNA licensing initiates replication fork assembly and DNA replication. This reaction promotes the loading of the hMCM2-7 complex on DNA, which represents the core of the replicative helicase that unwinds DNA during S-phase.
Jennifer N. Wells +11 more
doaj +1 more source
Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging
Genome Biology, 2020 Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan +12 more
doaj +1 more source
Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures
Nature Communications, 2022 Using single-molecule visualization and manipulation, Chang et al. show that the eukaryotic Smc5/6 complex preferentially binds to and stabilizes ssDNA-dsDNA junctions, which could serve as the molecular basis for its diverse roles in genome maintenance.
Jeremy T-H. Chang +8 more
doaj +1 more source