Results 61 to 70 of about 910,557 (358)

Drf1-dependent Kinase Interacts with Claspin through a Conserved Protein Motif [PDF]

, 2010
The Dbf4/Drf1-dependent kinase (DDK) is required for the initiation of DNA replication in eukaryotes. Another protein, Claspin, mediates the activation of a cellular checkpoint response to stalled replication forks and is also a regulator of replication.
Aparicio, Arias, Chini, Chini, Clarke, Daniel A. Gold, Gambus, Hodgson, Jeong, Jiang, Kastan, Katou, Kim, Kumagai, Kumagai, Kumagai, Kumagai, Kumagai, Kumagai, Lee, Lee, Lin, Lou, Masai, Masai, Melo, Montagnoli, Moyer, Osborn, Pacek, Petermann, Roberts, Sar, Sheu, Silva, Ström, Szyjka, Takahashi, Takahashi, Takeda, Tenca, Tourrière, Tsuji, Tsuji, Walter, William G. Dunphy, Yanow, Yoo, Zou   +48 more
core   +3 more sources

Replicating repetitive DNA

Nature Cell Biology, 2016
The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
Christian Speck, Silvia Tognetti, Silvia Tognetti   +2 more
openaire   +5 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology

Cell Reports, 2023
Summary: Rad24-RFC (replication factor C) loads the 9-1-1 checkpoint clamp onto the recessed 5′ ends by binding a 5′ DNA at an external surface site and threading the 3′ single-stranded DNA (ssDNA) into 9-1-1. We find here that Rad24-RFC loads 9-1-1 onto
Fengwei Zheng, Roxana E. Georgescu, Nina Y. Yao, Michael E. O’Donnell, Huilin Li   +4 more
doaj  

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough, Berezney, Brown, Cardoso, Chevalier, Cook, Coverley, Coverley, den Hollander, Dijkwel, Djeliova, Fujita, Furstenthal, Geng, Geng, Harper, Hozak, Krude, Lowe, Mailand, Mitsui, Moore, Parisi, Radichev, Sherr, Stoeber, Su, Takeda, Tatsumi, Wilmes, Wohlschlegel   +30 more
core   +3 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos [PDF]

, 2015
SummaryDuring cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Blow, J. Julian, Craig, Gillian, Gartner, Anton, Labib, Karim, Sonneville, Remi   +4 more
core   +4 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases

Cells, 2021
Multiple epigenetic pathways underlie the temporal order of DNA replication (replication timing) in the contexts of development and disease. DNA methylation by DNA methyltransferases (Dnmts) and downstream chromatin reorganization and transcriptional ...
Shin-ichiro Takebayashi, Tyrone Ryba, Kelsey Wimbish, Takuya Hayakawa, Morito Sakaue, Kenji Kuriya, Saori Takahashi, Shin Ogata, Ichiro Hiratani, Katsuzumi Okumura, Masaki Okano, Masato Ogata   +11 more
doaj   +1 more source

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei [PDF]

, 1992
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but
Alsner, Altschul, Ascoli, Beck, Bensch, Bestor, Bestor, Bestor, Bestor, Bestor, Brancolini, Bravo, Carmo-Fonseca, Carter, Cook, Czank, D'Andrea, Fox, Fu, Gauthier-Rouvière, Goldman, Gruenbaum, Hatton, Huang, Kaiser, Kambach, Kumar, Lasko, Lauster, Lawrence, Li, Li, Matthias, Meier, Mills, Morris, Nakamura, Nakayasu, Noguchi, O'Keefe, Ottiger, Peculis, Posfai, Roise, Sambrook, Saunders, Spector, Tomkinson, Tubo, Vissel, Wang, Weier   +51 more
core   +1 more source