Results 51 to 60 of about 710,489 (317)

DNAReplication: a database of information and resources for the eukaryotic DNA replication community

, 2009
DNAReplication (at http://www.dnareplication.net) has been set up as a freely available single resource to facilitate access to information on eukaryotic DNA replication.
Cotterill, S, Kearsey, Stephen E., Kearsey, SE, Kearsey, Stephen, Cotterill, Sue   +4 more
core   +1 more source

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. [PDF]

, 2007
BACKGROUND: The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was
Reina Hashimoto, Heck, Margarete M.S., Hashimoto, Reina, Sherkow, Jake, Sharron Vass, Heck, MM, Vass, Sharron, Hashimoto, R, Hashimoto Reina, Yamaguchi Masamitsu, Crevel, Gilles, Cotterill, S, Yamaguchi, M, Heck, Margarete M. S., Vass Sharron, Heck Margarete M.S., Sherkow Jake, Sherkow, Jacob S., Yamaguchi, Masamitsu, Sherkow, J, Cotterill Sue, Crevel Gilles, Margarete M S Heck, Crevel, G, Cotterill, Sue, Vass, S, Gilles Crevel, Margarete M.S. Heck, Jake Sherkow, Sue Cotterill, Masamitsu Yamaguchi   +30 more
core   +1 more source

Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

Genome Biology, 2020
Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan, Matthew J. Longley, Margaret H. Humble, Christopher A. Lavender, Adam Burkholder, Emma L. Blakely, Charlotte L. Alston, Grainne S. Gorman, Doug M. Turnbull, Robert McFarland, Robert W. Taylor, Thomas A. Kunkel, William C. Copeland   +12 more
doaj   +1 more source

Mechanisms of DNA replication [PDF]

Current Opinion in Chemical Biology, 2000
Advances in recent years have led to exciting new ideas about the initiation, regulation and coordination of DNA replication. Structural studies have yielded fascinating glimpses of replisome action. In addition, the involvement of replication proteins in other cellular processes has blurred the lines between replication, repair and recombination.
M J, Davey, M, O'Donnell
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

RAD51 restricts DNA over-replication from re-activated origins

The EMBO Journal
Eukaryotic cells rely on several mechanisms to ensure that the genome is duplicated precisely once in each cell division cycle, preventing DNA over-replication and genomic instability.
Sergio Muñoz, Elena Blanco-Romero, Daniel González-Acosta, Sara Rodriguez-Acebes, Diego Megías, Massimo Lopes, Juan Méndez   +6 more
doaj   +1 more source

Cdt1 stabilizes an open MCM ring for helicase loading

Nature Communications, 2017
The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading ...
Jordi Frigola, Jun He, Kerstin Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F. X. Diffley   +9 more
doaj   +1 more source

Replication of baculovirus DNA

Journal of General Virology, 1995
Introduction. The Baculoviridae is a diverse family of pathogens that are infectious for arthropods and are characterized by a complex replication cycle that culminates in the occlusion of virions in a crystalline protein matrix (Blissard & Rohrmann, 1990).
Kool, M., Ahrens, C.H., Vlak, J.M., Rohrmann, G.F.   +3 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos

, 2008
Background: Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time.
Labit, H, Goldar, A, Marheineke, K, Olivier Hyrien, Hélène Labit, Hyrien, O, Kathrin Marheineke, Arach Goldar   +7 more
core   +1 more source