Results 71 to 80 of about 566,456 (323)
Proteomic data on the nuclear interactome of human MCM9
Data in Brief, 2016 We present data relating to the interactome of MCM9 from the nuclei of human cells. MCM9 belongs to the AAA+ superfamily, and contains an MCM domain and motifs that may confer DNA helicase activity.
James R.A. Hutchins +6 more
doaj
A CDK-regulated chromatin segregase promoting chromosome replication
Nature Communications, 2021 How cells coordinate chromatin dynamics with the cell cycle machinery to promote genome duplication during S phase is still a matter of study. Here the authors reveal by in vitro reconstitution assays that the AAA + -ATPase containing Yta7 protein in S ...
Erika Chacin +11 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2013 Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin structure, and genome evolution. Recent advances in genome-scale mapping of replication kinetics have allowed these correlations to be explored in many species, cell types, and growth conditions, and these large data sets have allowed quantitative and ...
Rhind, Nicholas, Gilbert, David M.
openaire +4 more sources
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Purification and characterization of a novel archaeo-eukaryotic primase from Mimivirus [PDF]
arXiv, 2016 DNA replication is a process which is common to all domains of life yet different replication mechanisms are seen among different organisms. The mechanism of replication on such a structure is not yet understood. With this bigger picture in mind, we have initiated the characterization involved in DNA replication.
arxiv
Journal of Biological Chemistry, 1983 In this review, we will summarize new approaches to the study of DNA replication in yeast made possible by recombinant DNA technology, and in particular, survey results obtained with in vitro replication systems. Other recent reviews that summarize previous yeast replication studies are those of Fangman and Zakian and Petes.
openaire +3 more sources
DNA replication and beyond [PDF]
Nature Reviews Molecular Cell Biology, 2016 It turns out that Meselson and Stahl were not the first to show that DNA replicates semi-conservatively. The preceding experiment was almost forgotten, partly because it showed something incredible.
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Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing
Nature CommunicationsOrigin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment in S-phase.
L. Maximilian Reuter +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source