Results 81 to 90 of about 562,887 (224)
Nature Communications, 2016 In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork ...
Akshay K. Ahuja +10 more
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Mutagenesis and Metallic DNA [PDF]
arXiv, 2000 Positions of protons in DNA hydrogen bonds are fundamental for the fidelity of the replication process. Because the hydrogen bond is partially covalent the electronic structure of DNA plays an important role in the replication process. Current studies of electron transfer in DNA have shown that simple pictures based on independent electron physics are ...
arxiv
The Dynamic Replicon: adapting to a changing cellular environment [PDF]
arXiv, 2008 Eukaryotic cells are often exposed to fluctuations in growth conditions as well as endogenous and exogenous stress-related agents. In addition, during development global patterns of gene transcription change dramatically, and these changes are associated with altered patterns of DNA replication.
arxiv
DNA replication and recombination [PDF]
Nature, 2003 Knowledge of the structure of DNA enabled scientists to undertake the difficult task of deciphering the detailed molecular mechanisms of two dynamic processes that are central to life: the copying of the genetic information by DNA replication, and its reassortment and repair by DNA recombination.
openaire +3 more sources
High nucleotide skew palindromic DNA sequences function as replication origins due to their unzipping propensity [PDF]
arXivLocations of DNA replication initiation in prokaryotes, called "origins of replication", are well-characterized. However, a mechanistic understanding of the sequence-dependence of the local unzipping of double-stranded DNA, the first step towards replication initiation, is lacking.
arxiv
Quantum Effects and Genetics Code: Dynamics and Information Transfer in DNA Replication [PDF]
arXiv, 2006 The possible role of quantum effects in transfer of genetic information is studied. It's argued that the nucleotides selection during DNA replication is performed by means of proton tunneling between nucleotide and DNA-polimerase bound by hydrogen bonds.
arxiv
Force Induced DNA Melting [PDF]
arXiv, 2008 When pulled along the axis, double-strand DNA undergoes a large conformational change and elongates roughly twice its initial contour length at a pulling force about 70 pN. The transition to this highly overstretched form of DNA is very cooperative. Applying force perpendicular to the DNA axis (unzipping), double-strand DNA can also be separated into ...
arxiv
Proof that the Replication of DNA involves Separation of the Strands [PDF]
, 1962 John Cairns
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The rate of DNA replication at the molecular, chromosomal, cellular, and intercellular levels in regenerating rat liver. [PDF]
, 1967 William B. Looney +2 more
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In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias
Cell Reports, 2017 Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA ...
Sergio Muñoz +6 more
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