Results 181 to 190 of about 87,449 (274)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Molecular Characterization of a Restriction Endonuclease PsaI from <i>Pseudomonas anguilliseptica</i> KM9 and Sequence Analysis of the PsaI R-M System. [PDF]

Int J Mol Sci
Furmanek-Blaszk B, Mruk I, Sektas M.
europepmc   +1 more source

Partial NH2- and cooh-terminal sequence analyses of Eco RI DNA restriction and modification enzymes.

, 1981
Robert A. Rubin, Paul Modrich, Thomas Vanaman   +2 more
openalex   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates of <i>Borrelia afzelii</i> and <i>Borrelia garinii</i>. [PDF]

Curr Res Microb Sci
Ruivo M, Schötta AM, Stelzer T, Reiter M, Wijnveld M.   +4 more
europepmc   +1 more source

Fusion of GFP to the M.EcoKI DNA methyltransferase produces a new probe of Type I DNA restriction and modification enzymes

, 2010
Kai Chen, Gareth A. Roberts, Augoustinos S. Stephanou, Laurie P. Cooper, John H. White, David T. F. Dryden   +5 more
openalex   +1 more source

Integrative Approaches for DNA Sequence‐Controlled Functional Materials

Advanced Functional Materials, EarlyView.
DNA is emerging as a programmable building block for functional materials with applications in biomimicry, biochemical, and mechanical information processing. The integration of simulations, experiments, and machine learning is explored as a means to bridge DNA sequences with macroscopic material properties, highlighting current advances and providing ...
Aaron Gadzekpo, Ewa Anna Oprzeska‐Zingrebe, Mariana Kozlowska, Lennart Hilbert, Iliya D. Stoev   +4 more
wiley   +1 more source

Pathogen-induced hijacking of host SUMOylation: from molecular mechanisms and prospects for therapeutic modulation. [PDF]

Front Immunol
Padmakumar S, Madhavan A, Nair BG, Kumar GB.   +3 more
europepmc   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

From sequence to activity: the HgaI-homologous restriction modification system RM.MhoVI of Mycoplasma hominis. [PDF]

BMC Microbiol
Vogelgsang L, Dolgopolow-Schmidt M, Nisar A, Bäcker D, Dilthey AT, Henrich B.   +5 more
europepmc   +1 more source