Results 31 to 40 of about 185,882 (314)

Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]

, 2013
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
A Dürr, A Filla, A Saveliev, A Wong, AH Koeppen, Annalisa Pastore, C Sandi, Chiranjeevi Sandi, D Globisch, E Grabczyk, E Greene, E Kim, GN Filippova, H Chen, H Holemon, H Stroud, I Castaldo, I De Biase, I De Biase, J Robertson, JL Bradley, JU Guo, KE Szulwach, M Mellén, M Pandolfo, M Tahiliani, Mark A. Pook, MC Haffner, MR Branco, MV Evans-Galea, N Chia, PK Chan, R Sharma, RD Wells, Ricardo Mouro Pinto, S Al-Mahdawi, S Kriaucionis, Sahar Al-Mahdawi, T Wang, V Campuzano, V Campuzano, Y Huang   +41 more
core   +9 more sources

Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme. [PDF]

PLoS ONE, 2015
Type I restriction-modification enzymes are multifunctional heteromeric complexes with DNA cleavage and ATP-dependent DNA translocation activities located on motor subunit HsdR.
Eva Csefalvay, Mikalai Lapkouski, Alena Guzanova, Ladislav Csefalvay, Tatsiana Baikova, Igor Shevelev, Vitali Bialevich, Katsiaryna Shamayeva, Pavel Janscak, Ivana Kuta Smatanova, Santosh Panjikar, Jannette Carey, Marie Weiserova, Rüdiger Ettrich   +13 more
doaj   +1 more source

Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella [PDF]

, 2014
Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction–modification (R–M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R–M systems, highly
Cao, Bo, Cheng, Qiuxiang, Dedon, Peter C., DeMott, Michael S., Deng, Zixin, Gu, Chen, Yao, Fen, You, Delin, Zheng, Xiaoqing   +8 more
core   +1 more source

Alleviation of restriction by DNA condensation and non-specific DNA binding ligands [PDF]

, 2004
During conditions of cell stress, the type I restriction and modification enzymes of bacteria show reduced, but not zero, levels of restriction of unmethylated foreign DNA.
Dryden, D T F, Keatch, S A, Su, T J
core   +3 more sources

An alternative approach to study the enzymatic specificities of the CfrBI restriction–modification system

Heliyon, 2019
Restriction–modification systems (RMS) are the main gene-engineering tools and a suitable model to study the molecular mechanisms of catalysis and DNA–protein interactions.
Marina V. Zakharova, Irina V. Beletskaya, Elena M. Ibryashkina, Alexander S. Solonin   +3 more
doaj   +1 more source

Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities [PDF]

, 2015
The restriction-modification systems use epigenetic modification to distinguish between self and nonself DNA. A modification enzyme transfers a methyl group to a base in a specific DNA sequence while its cognate restriction enzyme introduces breaks in ...
Fukuyo, Masaki, Furuta, Yoshikazu, Hamakawa, Takeshi, Ide, Hiroshi, Ishikawa, Ken, Kobayashi, Ichizo, Nakano, Toshiaki, Watanabe-Matsui, Miki, Yano, Hirokazu, Zhang, Yingbiao   +9 more
core   +2 more sources

Structural and functional analysis of the symmetrical Type I restriction endonuclease R.EcoR124I_NT

PLoS ONE, 2012
Type I restriction-modification (RM) systems are comprised of two multi-subunit enzymes, the methyltransferase (∼160 kDa), responsible for methylation of DNA, and the restriction endonuclease (∼400 kDa), responsible for DNA cleavage. Both enzymes share a
James E Taylor, Anna Swiderska, Jean-Baptiste Artero, Philip Callow, Geoff Kneale   +4 more
doaj   +1 more source

Functional Traits Co-Occurring with Mobile Genetic Elements in the Microbiome of the Atacama Desert [PDF]

, 2019
Mobile genetic elements (MGEs) play an essential role in bacterial adaptation and evolution. These elements are enriched within bacterial communities from extreme environments. However, very little is known if specific genes co-occur with MGEs in extreme
Airo, Alessandro, Schloter, Michael, Schulze-Makuch, Dirk, Sáenz, Johan S., Vestergaard, Gisle   +4 more
core   +1 more source

A novel SfaNI-like restriction-modification system in Caldicellulosiruptor extents the genetic engineering toolbox for this genus

PLoS ONE, 2022
Caldicellulosiruptor is a genus of thermophilic to hyper-thermophilic microorganisms that express and secrete an arsenal of enzymes degrading lignocellulosic biomasses into fermentable sugars.
Steve Swinnen, Christian Zurek, Marco Krämer, Rebecca M. Heger, Jan-Eike Domeyer, Jan Ziegler, Vitali A. Svetlitchnyi, Albrecht Läufer   +7 more
doaj   +2 more sources

Analysis of the Campylobacter jejuni genome by SMRT DNA sequencing identifies restriction-modification motifs.

PLoS ONE, 2015
Campylobacter jejuni is a leading bacterial cause of human gastroenteritis. The goal of this study was to analyze the C. jejuni F38011 strain, recovered from an individual with severe enteritis, at a genomic and proteomic level to gain insight into ...
Jason L O'Loughlin, Tyson P Eucker, Juan D Chavez, Derrick R Samuelson, Jason Neal-McKinney, Christopher R Gourley, James E Bruce, Michael E Konkel   +7 more
doaj   +1 more source