Results 1 to 10 of about 1,001,170 (200)
Exoquence DNA sequencing [PDF]
Nucleic Acids Research, 1993 We have developed a strategy for DNA sequencing based on exonuclease III digestion followed by double strand specific endonuclease digestion and direct dideoxynucleotide sequencing reaction. This strategy eliminates the need for subcloning, oligonucleotide primers, and prior knowledge of the DNA to be sequenced.
C, Li, P W, Tucker
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Circulation, 2012 We are in the midst of a time of great change in genetics that may dramatically impact human biology and medicine. The completion of the human genome project,1,2 the development of low cost, high-throughput parallel sequencing technology, and large-scale studies of genetic variation3 have provided a rich set of techniques and data for the study of ...
Frederick E, Dewey +4 more
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Distinguish Coding And Noncoding Sequences In A Complete Genome Using Fourier Transform [PDF]
, 2007 A Fourier transform method is proposed to distinguish coding and non-coding sequences in a complete genome based on a number sequence representation of the DNA sequence proposed in our previous paper (Zhou et al., J. Theor. Biol.
Anh, Vo +3 more
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A novel mathematical tool for generating highly conserved protein domain via different organismal genomic landscapes [PDF]
, 2010 Darwinian evolution hypothesizes that a short stretch of DNA was first constructed and then it expanded to give rise to a long strand. This long strand then produced a mix of exons, introns and repetitive DNA sequence.
Arunava Goswami +3 more
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Investigations into the molecular effects of single nucleotide polymorphism [PDF]
, 2000 Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe
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Competition between B-Z and B-L transitions in a single DNA molecule: Computational studies [PDF]
, 2016 Under negative torsion, DNA adopts left-handed helical forms, such as Z-DNA and L-DNA. Using the random copolymer model developed for a wormlike chain, we represent a single DNA molecule with structural heterogeneity as a helical chain consisting of ...
Hong, Seok Cheol +5 more
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Sequence Effects on DNA Entropic Elasticity [PDF]
, 1997 DNA stretching experiments are usually interpreted using the worm-like chain model; the persistence length A appearing in the model is then interpreted as the elastic stiffness of the double helix.
B. Alberts +23 more
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Proceedings of the National Academy of Sciences, 2014 The well-preserved mummy of an old man (Upper) is displayed in an exhibition in Denmark’s National Museum. The mummy was removed, as displayed, from an excavation in 1875 at Borum Eshoj, near Aarhus, Denmark. Carpenter and colleagues used hair samples from the mummy to isolate ancient DNA and validate the technique.
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Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing [PDF]
, 2017 Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer read lengths than conventional methods, less GC bias, and the ability to read DNA base modifications.
Henley, Robert Y. +4 more
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Simulation and analysis of in vitro DNA evolution [PDF]
, 2003 We study theoretically the in vitro evolution of a DNA sequence by binding to a transcription factor. Using a simple model of protein-DNA binding and available binding constants for the Mnt protein, we perform large-scale, realistic simulations of ...
Chao Tang +6 more
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