Results 41 to 50 of about 2,635,192 (296)

Auto Sequencer: A DNA Sequence Alignment and Assembly Tool

Spectrum, 2018
The process of determining the exact order of nucleotides in DNA is a crucial component of a wide variety of research applications known as DNA sequencing.
Abhi Aggarwal, Landon Zarowny, Robert E Campbell   +2 more
doaj   +1 more source

Inhomogeneous DNA: conducting exons and insulating introns

, 2009
Parts of DNA sequences known as exons and introns play very different role in coding and storage of genetic information. Here we show that their conducting properties are also very different.
A. A. Krokhin, B. L. Al’tshuler, D. J. Thouless, F. M. Izrailev, L. Brillouin, O. V. Usatenko, V. A. Yampol’skii, V. M. K. Bagci   +7 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]

, 2017
Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A, Lorenzo, Claire, Zheng, Yuxuan   +2 more
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Local alignment of generalized k-base encoded DNA sequence

BMC Bioinformatics, 2010
Background DNA sequence comparison is a well-studied problem, in which two DNA sequences are compared using a weighted edit distance. Recent DNA sequencing technologies however observe an encoded form of the sequence, rather than each DNA base ...
Nelson Stanley F, Homer Nils, Merriman Barry   +2 more
doaj   +1 more source

From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions [PDF]

, 2009
©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Sarai, AV Morozov, BW Matthews, BW Matthews, CG Kalodimos, CH Yan, CO Pabo, E Fraenkel, E Katchalski-Katzir, FK Winkler, H Tjong, I Bonnet, IB Kuznetsov, Ilya Vakser, J Gorman, J Skolnick, J Skolnick, JE Donald, Jeffrey Skolnick, JJ Havranek, JS Lamoureux, JS Lamoureux, M Billeter, M Gao, M van Dijk, MJ Sippl, Mu Gao, N Bhardwaj, NC Horton, NM Luscombe, NP Stanford, O Givaty, P Aloy, P Rotkiewicz, PH von Hippel, R Mendez, R Samudrala, RMA Knegtel, S Ahmad, S Jones, SE Halford, SJ Hubbard, TA Robertson, TW Siggers, W Humphrey, WJ Lane, XJ Lu, Y Zhang, Y Zhang, ZJ Liu   +49 more
core   +4 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Spatial Control of DNA Reaction Networks by DNA Sequence

Molecules, 2012
We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at ...
Andrew D. Ellington, Xi Chen, Peter B. Allen   +2 more
doaj   +1 more source

Information decomposition of symbolic sequences

, 2003
We developed a non-parametric method of Information Decomposition (ID) of a content of any symbolical sequence. The method is based on the calculation of Shannon mutual information between analyzed and artificial symbolical sequences, and allows the ...
Adams, Almirantis, Audi, Benson, Benson, Chaley, Chechetkin, Cole, Conway, Coward, Dodin, Dodin, E.V. Korotkov, Fraser, Glaser, Grosse, Heringa, Herren, Hertz, Herzel, Jackson, Junker, Korotkova, Kullback, Lobzin, Lotman, M.A. Korotkova, Margot, Marple, McLachlan, N.A. Kudryashov, Ng, Pennisi, Presta, Rackovsky, Ramakrishna, Rashid, Silverman, Stoesser, Tiwari, Tomb, Trifonov, Venter, Voss, Wang, Weiss, Yaglom, Zirmunsky   +47 more
core   +1 more source