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A Markov analysis of DNA sequences
Journal of Theoretical Biology, 1983We present a model by which we look at the DNA sequence as a Markov process. It has been suggested by several workers that some basic biological or chemical features of nucleic acids stand behind the frequencies of dinucleotides (doublets) in these chains.
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Mixed Model Analysis of DNA Sequence Evolution
Biometrics, 1995Nucleotides in a DNA sequence may be changing at different rates, because they are located in different structural and functional regions of the gene, and are thus subject to different mutational pressures or selective restrictions. Knowledge of substitution rates at specific sites is important for understanding the forces and mechanisms that have ...
Yang, Ziheng, Wang, Tianlin
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2009
In this chapter we introduce some of the elementary concepts for analyzing DNA sequences in terms of “words” of length 1 (bases), 2 (base pairs), 3 (triplets, such as codons), restriction sites, etc. The analysis uses some of the basic probability concepts that we have worked with in the previous chapter.
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In this chapter we introduce some of the elementary concepts for analyzing DNA sequences in terms of “words” of length 1 (bases), 2 (base pairs), 3 (triplets, such as codons), restriction sites, etc. The analysis uses some of the basic probability concepts that we have worked with in the previous chapter.
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Visualization and analysis of DNA sequences using DNA walks
Journal of the Franklin Institute, 2004zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Berger JA +3 more
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DNA Sequence‐Based Phenotypic Association Analysis
2008The availability of cost-effective, high-throughput genotyping technologies has generated a tremendous amount of interest in genetic association studies. This interest has led to the belief that one could possibly test thousands to millions of representative polymorphic sites on the genome for association with a trait or disease in order to identify ...
Nicholas J, Schork +2 more
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Fractals in DNA sequence analysis
Chinese Physics, 2002Fractal methods have been successfully used to study many problems in physics, mathematics, engineering, finance and even in biology. There has been an increasing interest in unravelling the mysteries of DNA; for example, how can we distinguish coding and noncoding sequences and the problems of classification and evolution relationship of organisms are
Zu, Zu-Guo +3 more
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DNA Sequence Polymorphism Analysis Using DnaSP
2009The analysis of DNA sequence polymorphisms and SNPs (single nucleotide polymorphisms) can provide insights into the evolutionary forces acting on populations and species. Available population-genetic methods, and particularly those based on the coalescent theory, have become the primary framework to analyze such DNA polymorphism data.
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Double‐Stranded
AbstractThere are several different methods for analyzing the sequence of cloned DNA segments. For analysis of immunoglobulin variable (V) regions, double‐stranded DNA sequencing is routinely used. Although this method does not yield the longest DNA sequences, it is easy and provides sufficient information to determine the correct sequence.
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Fluorescence detection in automated DNA sequence analysis
Nature, 1986L. Smith +8 more
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