Results 111 to 120 of about 1,359,741 (317)

Evolution of repetitive DNA in angiosperms: examples from Nicotiana allopolyploids [PDF]

, 2012
PhDAllopolyploidy, interspecific hybridisation coupled with genome multiplication, is a prevailing force in the evolution of angiosperms. This thesis examines the consequences of allopolyploidy at the genomic level.
Renny-Byfield, Simon
core  

QTrim : a novel tool for the quality trimming of sequence reads generated using the Roche/454 sequencing platform [PDF]

, 2014
Background Many high throughput sequencing (HTS) approaches, such as the Roche/454 platform, produce sequences in which the quality of the sequence (as measured by a Phred-like quality scores) decreases linearly across a sequence read.
Grace P McCormack, Lubinsky, Baruch, Bansode, Vijay B., Mónica BJ Moinz, McCormack, Grace P., Vijay B Bansode, Travers, Simon A., Simon A Travers, Ram Shrestha, Baruch Lubinsky, Shrestha, Ram, Moinz, Mónica B. J.   +11 more
core   +1 more source

Duplication in DNA Sequences

, 2008
Duplication and repeat-deletion are the basic models of errors occurring during DNA replication from the viewpoint of formal languages. During DNA replication, subsequences of a strand of DNA may be copied several times (duplication) or skipped (repeat-deletion). Iterated duplication and repeat-deletion have been well-studied, but little is known about
Masami Ito, Lila Kari, Zachary Kincaid, Shinnosuke Seki 0001   +3 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Incorporating DNA Sequencing into Current Prenatal Screening Practice for Down's Syndrome [PDF]

, 2013
PMCID: PMC3604109This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Jonathan P. Bestwick (130538), Wald, NJ, Bestwick, JP, Jonathan P Bestwick, Nicholas J Wald, Jonathan P. Bestwick, Wald Nicholas J., Nicholas J. Wald (130535), Nicholas J. Wald, Bestwick Jonathan P.   +9 more
core   +1 more source

Genome and tissue-specific transcriptomes of the large-polyp coral, Fimbriaphyllia (Euphyllia) ancora: a recipe for a coral polyp

Communications Biology
Coral polyps are composed of four tissues; however, their characteristics are largely unexplored. Here we report biological characteristics of tentacles (Te), mesenterial filaments (Me), body wall (Bo), and mouth with pharynx (MP), using comparative ...
Shinya Shikina, Yuki Yoshioka, Yi-Ling Chiu, Taiga Uchida, Emma Chen, Yin-Chu Cheng, Tzu-Chieh Lin, Yu-Ling Chu, Miyuki Kanda, Mayumi Kawamitsu, Manabu Fujie, Takeshi Takeuchi, Yuna Zayasu, Noriyuki Satoh, Chuya Shinzato   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The habu genome reveals accelerated evolution of venom protein genes

Scientific Reports, 2018
Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture.
Hiroki Shibata, Takahito Chijiwa, Naoko Oda-Ueda, Hitomi Nakamura, Kazuaki Yamaguchi, Shousaku Hattori, Kazumi Matsubara, Yoichi Matsuda, Akifumi Yamashita, Akiko Isomoto, Kazuki Mori, Kosuke Tashiro, Satoru Kuhara, Shinichi Yamasaki, Manabu Fujie, Hiroki Goto, Ryo Koyanagi, Takeshi Takeuchi, Yasuyuki Fukumaki, Motonori Ohno, Eiichi Shoguchi, Kanako Hisata, Noriyuki Satoh, Tomohisa Ogawa   +23 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source