Results 171 to 180 of about 37,201 (270)

Direct Comparison of d-DNA and l-DNA Strand-Displacement Reactions in Living Mammalian Cells. [PDF]

ACS Synth Biol, 2021
Zhong W, Sczepanski JT.
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand-Displacement Reaction. [PDF]

Angew Chem Int Ed Engl
Ding Y, Heng Y, Wong KY, Chen Q, Liu J.
europepmc   +1 more source

Kinetics of Toehold-Mediated DNA Strand Displacement Depend on Fe^II₄L₄ Tetrahedron Concentration. [PDF]

Nano Lett, 2021
Zhu J, Bošković F, Nguyen BT, Nitschke JR, Keyser UF.   +4 more
europepmc   +1 more source

Twinkle-Catalyzed Toehold-Mediated DNA Strand Displacement Reaction

Strand exchange between homologous nucleic acid sequences is the basis for cellular DNA repair, recombination, and genome editing technologies. Specialized enzymes catalyze cellular strand exchange; however, the reaction occurs spontaneously when a ...
Anupam Singh (328008), Smita S. Patel (21893), Gayatri Patel (8158)   +2 more
core   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Kinetic Proofreading can Enhance Specificity in a Non-enzymatic DNA Strand Displacement Network

, 2023
Mukherjee R, Sengar A, Cabello-García J, Ouldridge TE.   +3 more
europepmc   +1 more source

DNA Strand Displacement with Base Pair Stabilizers: Purine-2,6-Diamine and 8-Aza-7-Bromo-7-Deazapurine-2,6-Diamine Oligonucleotides Invade Canonical DNA and New Fluorescent Pyrene Click Sensors Monitor the Reaction. [PDF]

Chemistry, 2022
Zhang A, Kondhare D, Leonard P, Seela F.
europepmc   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Design of mismatch closure for enhanced specificity in DNA strand displacement reactions. [PDF]

Nucleic Acids Res
Yu H, Han X, Zhang L, Yin N, Wang L, Lv K, Wu Y, Bai D, Wang W, Huang Y, Hu X, Weng Z, Zhang C, Yang G, Chen T, Xie G.   +15 more
europepmc   +1 more source