Results 171 to 180 of about 6,016,549 (343)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis. [PDF]

Nat Commun
Frevert Z, Reusch DT, Gildenberg MS, Jordan SM, Ryan BJ, Freudenthal BD, Washington MT.   +6 more
europepmc   +1 more source

Break-induced replication occurs by conservative DNA synthesis

Proceedings of the National Academy of Sciences of the United States of America, 2013
R. Donnianni, L. Symington
semanticscholar   +1 more source

Enzymatic breakage and joining of deoxyribonucleic acid. IV. DNA synthesis in E. coli infected with ligase-negative mutants of phage T4. [PDF]

, 1968
Yukito Masamune, C C Richardson
openalex   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Properties of Maxentropic DNA Synthesis Codes. [PDF]

Entropy (Basel)
Schouhamer Immink K, Weber JH, Cai K.
europepmc   +1 more source

Reverse transcriptases prime DNA synthesis. [PDF]

Nucleic Acids Res, 2023
Zabrady M, Zabrady K, Li AWH, Doherty AJ.   +3 more
europepmc   +1 more source

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

Nature Structural &Molecular Biology, 2013
Matthew Hogg, Pia Osterman, G. Bylund, R. A. Ganai, Else-Britt Lundström, E. Sauer-Eriksson, E. Johansson   +6 more
semanticscholar   +1 more source

Radiation-induced Chromosomal Aberration in Relation to DNA Synthesis [PDF]

, 1966
Koji Yamamoto, Hikoyuki YAMAGUCHI
openalex   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source