Results 121 to 130 of about 2,766,615 (303)

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Numerical study of linear and circular model DNA chains confined in a slit: metric and topological properties

, 2012
Advanced Monte Carlo simulations are used to study the effect of nano-slit confinement on metric and topological properties of model DNA chains. We consider both linear and circularised chains with contour lengths in the 1.2--4.8 $\mu$m range and slits ...
Arsuaga J., Arsuaga J., Atapour M., Bonthuis D. J., Chen J. Z. Y., Clisby N., Cristian Micheletti, Daoud M., De Gennes P., de Gennes P.-G., Deguchi T., Dimitrov D. I., Drube F., Enzo Orlandini, Ercolini E., Frank-Kamenetskii M. D., Fu J., Gelbart W. M., Grosberg A., Grosberg A. Y., Haber C., Han J., Janse van Rensburg E. J., Jo K., Koniaris K., Krishnan M., Leforestier A., Leforestier A., Lin P.-K., Liu Z., Liu Z., Maier B., Maier B., Marcone B., Marenduzzo D., Marenduzzo D., Matthews R., Matthews R., Micheletti C., Micheletti C., Micheletti C., Michels J. P. J., Millett K., Moore N. T., Odijk T., Odijk T., Orlandini E., Rawdon E., Rawdon E. J., Reisner W., Rollins G. C., Rosa A., Rybenkov V. V., Schoch R. B., Schvartman J. B., Shimamura M. K., Soteros C., Strey H. H., Sumners D. W., Tang J., Taylor W. R., Tesi M. C., Tesi M. C., Tesi M. C., Toan N. M., Tubiana L., Tubiana L., Valle F., Virnau P., Virnau P., Wang Y., Witz G., Witz G., Zwolak M.   +73 more
core   +1 more source

Single-molecule Measurements of DNA Topology and Topoisomerases*

Journal of Biological Chemistry, 2010
Topological properties of DNA influence its mechanical and biochemical interactions. Genomic DNA is maintained in a state of topological homeostasis by topoisomerases and is subjected to mechanical stress arising from replication and segregation. Despite
K. Neuman
semanticscholar   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Structural Coupling between RNA Polymerase Composition and DNA Supercoiling in Coordinating Transcription: a Global Role for the Omega Subunit?

mBio, 2011
In growing bacterial cells, the global reorganization of transcription is associated with alterations of RNA polymerase composition and the superhelical density of the DNA.
Marcel Geertz, Andrew Travers, Sanja Mehandziska, Patrick Sobetzko, Sarath Chandra Janga, Nobuo Shimamoto, Georgi Muskhelishvili   +6 more
doaj   +1 more source

Two Rules on the Protein-Ligand Interaction [PDF]

, 2008
So far, we still lack a clear molecular mechanism to explain the protein-ligand interaction on the basis of electronic structure of a protein. By combining the calculation of the full electronic structure of a protein along with its hydrophobic pocket ...
Lily Zhang, Lina Xu, Linxiang Zhou, Xiaodong Pang, Xinyi Zhang   +4 more
core   +1 more source

Theoretical models of DNA topology simplification by type IIA DNA topoisomerases

Nucleic Acids Research, 2009
It was discovered 12 years ago that type IIA topoisomerases can simplify DNA topology—the steady-state fractions of knots and links created by the enzymes are many times lower than the corresponding equilibrium fractions.
A. Vologodskii
semanticscholar   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source