Results 141 to 150 of about 124,583 (279)

Effects of DNA Topology on Transcription from rRNA Promoters in Bacillus subtilis. [PDF]

Microorganisms, 2021
Sudzinová P, Kambová M, Ramaniuk O, Benda M, Šanderová H, Krásný L.   +5 more
europepmc   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

H2A.Z-nucleosomes are stabilized by the superhelicity-dependent DNA binding of the C-terminal tail of the histone variant

Nucleus
Using an in situ nucleosome stability assay based on salt extraction, we identified distinct stability features of H2A.Z-containing nucleosomes linked to alternative interactions of the histone variant’s C-terminal tail (Imre et al., Nat. Commun., 2024).
Ibtissem Benhamza, Laszlo Imre, Zutao Yu, Peter Nanasi, Pialy Sen, Kata Nora Enyedi, Katalin Goda, György Vamosi, Gabor Szabo   +8 more
doaj   +1 more source

Probing E. coli SSB protein-DNA topology by reversing DNA backbone polarity. [PDF]

Biophys J, 2021
Kozlov AG, Lohman TM.
europepmc   +1 more source

In vivo DNA topology and conformations of chromatin

, 2017
Trabajo presentado en el EMBO Workshop: DNA topoisomerases and DNA topology, celebrado en Les Diablerets (Suiza), del 17 al 21 de septiembre de 2017In contrast to our approximated view of the topology and conformations of naked DNA molecules in vitro ...
Dyson, Sílvia, Valdés, Antonio, Martínez-García, Belén, Joshi, Ricky S., Segura, Joana, Roca, Joaquim   +5 more
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Mechanozyme: An Artificial Enzyme With a Mechanophore Framework

Advanced Science, EarlyView.
Mechanical destabilization of a G‐quadruplex mechanophore in a DNAzyme markedly boosts its catalytic activity, demonstrating “mechanozymes” as artificial enzymes whose functions are modulated by mechanical stress exerted by ultrasonication. This mechanozyme principle is broadly applicable to control biomolecular activities.
Jiahao Ji, Pravin Pokhrel, Sajan Shakya, Bishal Pokhrel, Grinsun Sharma, Pratiksha Chaudhary, Hao Shen, Hanbin Mao   +7 more
wiley   +1 more source

Molecular Mimics: How Viral Genomes Dupe Their Host by Usurping CTCF to Establish Infection

Viruses
The eukaryotic genome is organized into distinct structural units dictated by architectural proteins. The major host architectural protein CCCTC-binding factor (CTCF) is usurped by DNA viruses to regulate viral gene expression.
Clairine I. S. Larsen, Rhiannon R. Abrahams, Kinjal Majumder   +2 more
doaj   +1 more source

Top1-PARP1 association and beyond: from DNA topology to break repair. [PDF]

NAR Cancer, 2021
Chowdhuri SP, Das BB.
europepmc   +1 more source

Topology matters: Some aspects of DNA physics

, 2003
Biological cells, in some sense, are all about topology: Biomembranes separating different volumes from one another, ions or even macromolecules having to cross these membranes in controlled fashion through membrane pores; or certain proteins moving ...
Metzler, R, Ralf Metzler
core   +1 more source