Results 1 to 10 of about 2,307,592 (280)
DNA topoisomerases as molecular targets for anticancer drugs [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells ...
Kamila Buzun +3 more
doaj +5 more sources
DNA topoisomerases participate in fragility of the oncogene RET. [PDF]
PLoS ONE, 2013 Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Laura W Dillon +4 more
doaj +10 more sources
EcoSal Plus, 2015 DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage of a single- or double-strand segment of DNA through this transient break, stabilized by DNA-protein ...
Bush NG, Evans-Roberts K, Maxwell A.
europepmc +4 more sources
DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. [PDF]
Bioessays, 2021 DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism.
McKie SJ, Neuman KC, Maxwell A.
europepmc +2 more sources
Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA. [PDF]
J Virol, 2019 Persistent HBV infection relies on stable maintenance and proper functioning of a nuclear episomal form of the viral genome called cccDNA, the most stable HBV replication intermediate.
Sheraz M +4 more
europepmc +2 more sources
Our Evolving Understanding of the Mechanism of Quinolones [PDF]
Antibiotics, 2018 The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez +2 more
doaj +3 more sources
Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases. [PDF]
Curr Genomics, 2017 DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g.
Jain CK, Majumder HK, Roychoudhury S.
europepmc +2 more sources
EcoSal Plus, 2009 DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts +1 more
semanticscholar +4 more sources
Transcription, 2013 Chromatin is dynamically changing its structure to accommodate and control DNA-dependent processes inside of eukaryotic cells. These changes are necessarily linked to changes of DNA topology, which might itself serve as a regulatory signal to be detected by proteins.
Laura, Baranello +2 more
openaire +3 more sources
DNA-Topology Simplification by Topoisomerases [PDF]
Molecules, 2021 The topological properties of DNA molecules, supercoiling, knotting, and catenation, are intimately connected with essential biological processes, such as gene expression, replication, recombination, and chromosome segregation. Non-trivial DNA topologies
Andreas Hanke +2 more
doaj +3 more sources