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Supercoiled DNA recognition and cleavage control in topoisomerase VI [PDF]
Nature CommunicationsType II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively ...
Daniel E. Richman +10 more
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DNA binding and cleavage mechanism of DNA topoisomerase VI, an evolutionary counterpart of Spo11/Wadjet/Gabija systems [PDF]
Structural DynamicsType II topoisomerases resolve DNA supercoiling and chromosome entanglements. Type IIB topoisomerases, exemplified by Top6, are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 subunits ...
Daniel E Richman +7 more
doaj +2 more sources
Bacterial type II topoisomerases cleave DNA in a species-specific manner. [PDF]
Nucleic Acids ResAbstract The type II topoisomerases, gyrase and topoisomerase IV, are essential enzymes in nearly all bacteria and are the targets of fluoroquinolones, which are some of the most widely prescribed broad-spectrum antibacterials in clinical use.
Morgan IL +4 more
europepmc +4 more sources
Structural basis of gate-DNA breakage and resealing by type II topoisomerases. [PDF]
PLoS ONE, 2010 Type II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA replication, recombination and transcription. They change DNA topology by forming a transient covalent cleavage complex with a gate-DNA duplex that allows transport of a ...
Ivan Laponogov +5 more
doaj +4 more sources
Molecular Docking for the Development of Alternative Therapies against Leishmaniasis
Chemistry Proceedings, 2023 Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata +3 more
doaj +1 more source
Structural study of Topoisomerase IV-DNA-Levofloxacin complexes from Streptococcus pneumoniae [PDF]
E3S Web of Conferences, 2019 S. pneumoniae is an important pathogen causing pulmonary infection, acute otitis media and purulent meningitis in infants and children. Type II topoisomerases are enzymes that play essential roles in DNA replication, chromosome segregation and ...
Wang Xilan
doaj +1 more source
Topological Process of Splitting DNA-Links
Biomath, 2022 A DNA replicon is modeled by a special type of 2-component link, called a DNA-link, in which two circles form a double helix around a trivial center core curve.
Abdul Adheem Mohamad, Tsukasa Yashiro
doaj +1 more source
Data of transcriptional effects of the merbarone-mediated inhibition of TOP2
Data in Brief, 2022 Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands.
Fernando M. Delgado-Chaves +6 more
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Biology, 2021 DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined.
Jorge Cebrián +5 more
doaj +1 more source
eLife, 2022 Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong +4 more
doaj +1 more source