Results 21 to 30 of about 9,418 (226)
Chromatinization modulates topoisomerase II processivity
Nature Communications, 2023 Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress. While cellular processes constantly create varying torsional stress, how this variation impacts type IIA topoisomerase function ...
Jaeyoon Lee +10 more
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Cryo-EM structures of African swine fever virus topoisomerase
mBio, 2023 Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential role in resolving the topological problems of DNA. The viral type II topoisomerase encoded by the African swine fever virus (ASFV) is critical for viral ...
Yan Zhao +5 more
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Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage
eLife, 2018 Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination. Topo
Timothy J Wendorff, James M Berger
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DNA topoisomerase inhibitors: biflavonoids from Ouratea species
Brazilian Journal of Medical and Biological Research, 2002 Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg +6 more
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Mechanism of type II DNA topoisomerases: a tale of two gates [PDF]
Structure, 1994 DNA topoisomerases are fascinating enzymes involved in many cellular processes including replication, transcription, and genetic recombination. They are capable of catalyzing topological rearrangements of DNA such as relaxation of supercoiled DNA and catenation and decatenation of DNA rings [1xCozzarelli, N.R. and Wang, J.C. (eds). See all References[1]
C D, Lima, A, Mondragón
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Methanosarcina acetivorans C2A topoisomerase IIIα, an archaeal enzyme with promiscuity in divalent cation dependence. [PDF]
PLoS ONE, 2011 Topoisomerases play a fundamental role in genome stability, DNA replication and repair. As a result, topoisomerases have served as therapeutic targets of interest in Eukarya and Bacteria, two of the three domains of life.
Raymond Morales +3 more
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Binding of two DNA molecules by type II topoisomerases for decatenation [PDF]
Nucleic Acids Research, 2012 Topoisomerases (topos) maintain DNA topology and influence DNA transaction processes by catalysing relaxation, supercoiling and decatenation reactions. In the cellular milieu, division of labour between different topos ensures topological homeostasis and control of central processes.
Kumar, Rupesh +4 more
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Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
Nature Communications, 2018 Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-
Shin-Fu Chen +7 more
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Tightening of DNA knots by supercoiling facilitates their unknotting by type II DNA topoisomerases [PDF]
Proceedings of the National Academy of Sciences, 2011 Using numerical simulations, we compare properties of knotted DNA molecules that are either torsionally relaxed or supercoiled. We observe that DNA supercoiling tightens knotted portions of DNA molecules and accentuates the difference in curvature between knotted and unknotted regions. The increased curvature of knotted regions is expected to make them
Witz G, Dietler G, Stasiak A
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Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.
PLoS ONE, 2010 BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts +4 more
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