Results 21 to 30 of about 16,951 (259)

Mechanism of topology simplification by type II DNA topoisomerases [PDF]

Proceedings of the National Academy of Sciences, 2001
Type II DNA topoisomerases actively reduce the fractions of knotted and catenated circular DNA below thermodynamic equilibrium values. To explain this surprising finding, we designed a model in which topoisomerases introduce a sharp bend in DNA. Because the enzymes have a specific orientation relative to the bend, they act like Maxwell's demon ...
A V, Vologodskii, W, Zhang, V V, Rybenkov, A A, Podtelezhnikov, D, Subramanian, J D, Griffith, N R, Cozzarelli   +6 more
openaire   +2 more sources

Chromatinization modulates topoisomerase II processivity

Nature Communications, 2023
Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress. While cellular processes constantly create varying torsional stress, how this variation impacts type IIA topoisomerase function ...
Jaeyoon Lee, Meiling Wu, James T. Inman, Gundeep Singh, Seong ha Park, Joyce H. Lee, Robert M. Fulbright, Yifeng Hong, Joshua Jeong, James M. Berger, Michelle D. Wang   +10 more
doaj   +1 more source

Pif1-Family helicases support fork convergence during DNA replication termination in eukaryotes [PDF]

, 2019
The convergence of two DNA replication forks creates unique problems during DNA replication termination. In E. coli and SV40, the release of torsional strain by type II topoisomerases is critical for converging replisomes to complete DNA synthesis, but ...
Baxter, Jonathan, Deegan, Tom D, Labib, Karim P M, Ortiz Bazán, María Ángeles, Yeeles, Joseph T P   +4 more
core   +6 more sources

Restoration of Topoisomerase 2 Function by Complementation of Defective Monomers in Drosophila [PDF]

, 2014
Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one ...
Geyer, Pamela K., Hohl, Amber M., Hsieh, Tao-Shih, Morris, James, Soshnev, Alexey A., Thompson, Morgan, Wu, C.-ting, Wu, Jianhong   +7 more
core   +1 more source

Machines on Genes: Enzymes that Make, Break and Move DNA and RNA [PDF]

, 2010
As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of remarkable ...
Bates, Belousoff, Ben F. Luisi, Lilley, Marshall, Olorunniji, Rice, Richard P. Bowater, Sherratt, Smith, Szczelkun, Tomlinson, W. Marshall Stark, Weinzierl   +13 more
core   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly, A Hellman, A Helmrich, AA Burrow, AJ Swerdlow, AT Jonstrup, AY Chen, BH Long, C Pondarré, CH Cheng, Christine E. Lehman, CM Caudill, D Mishmar, D Vane, DJ Mulvihill, E Grabczyk, E Zlotorynski, F de Vathaire, F Pelliccia, FH Drake, FM Bar, G Abdurashidova, G Capranico, GR Bignell, GR Sutherland, H Zhang, HY Wu, I Bongarzone, J Sambrook, JC Wang, JM Allan, JM Fortune, K Reddy, K Takeuchi, KR Hande, KW Gow, L Enewold, L Postow, Laura W. Dillon, LB Travis, Le Beau, Levi C. T. Pierce, LF Liu, LW Dillon, LW Dillon, M Drolet, M Gandhi, M Zuker, MB Smith, MD Been, MD Been, MF Arlt, MN Nikiforova, MS Kim, NR Lemoine, O Handt, P Boffetta, PA Smanik, R Garcia-Carbonero, R Venkitaraman, RT Hay, S Anderson, S Corbin, S Klugbauer, S McAvoy, S Tuduri, S Wada, SG Durkin, SG Durkin, SJ Froelich-Ammon, SM Jhiang, SM Vos, SN Shah, T Kohno, T Kondo, T Syrovets, TW Glover, TW Glover, Valentin V Rybenkov, X Li, Y Lin, Y Lin, YE Nikiforov, YE Nikiforov, YE Nikiforov, Yuh-Hwa Wang, Yuri E. Nikiforov   +86 more
core   +8 more sources

Electrostatics of DNA–DNA juxtapositions: consequences for type II topoisomerase function [PDF]

Journal of Physics: Condensed Matter, 2006
Type II topoisomerases resolve problematic DNA topologies such as knots, catenanes, and supercoils that arise as a consequence of DNA replication and recombination. Failure to remove problematic DNA topologies prohibits cell division and can result in cell death or genetic mutation. Such catastrophic consequences make topoisomerases an effective target
Graham L, Randall, B Montgomery, Pettitt, Gregory R, Buck, E Lynn, Zechiedrich   +3 more
openaire   +2 more sources

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

eLife, 2018
Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination. Topo
Timothy J Wendorff, James M Berger
doaj   +1 more source

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability [PDF]

, 2015
Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA
Anna L. Chambers, Hiasa, Jessica A. Downs, Jonathan Baxter, Sahar Mansoubi, Stephanie A. Schalbetter   +5 more
core   +3 more sources