Results 1 to 10 of about 90,099 (199)

How enzymatic activity is involved in chromatin organization

eLife, 2022
Spatial organization of chromatin plays a critical role in genome regulation. Previously, various types of affinity mediators and enzymes have been attributed to regulate spatial organization of chromatin from a thermodynamics perspective.
Rakesh Das, Takahiro Sakaue, GV Shivashankar, Jacques Prost, Tetsuya Hiraiwa   +4 more
doaj   +1 more source

The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity

Life, 2022
Aeroplysinin-1 is a brominated isoxazoline alkaloid that has exhibited a potent antitumor cell effect in previous reports. We evaluated the cytotoxicity of aeroplysinin-1 against leukemia and prostate cancer cells in vitro. This marine alkaloid inhibited
Shou-Ping Shih, Mei-Chin Lu, Mohamed El-Shazly, Yu-Hsuan Lin, Chun-Lin Chen, Steve Sheng-Fa Yu, Yi-Chang Liu   +6 more
doaj   +1 more source

Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity

Pathogens, 2021
In the last few years, increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory.
Iwona Gabriel, Kamila Rząd, Ewa Paluszkiewicz, Katarzyna Kozłowska-Tylingo   +3 more
doaj   +1 more source

The role of isoflavones in augmenting the effects of radiotherapy

Frontiers in Oncology, 2023
Cancer is one of the major health problems and the second cause of death worldwide behind heart disease. The traditional soy diet containing isoflavones, consumed by the Asian population in China and Japan has been identified as a protective factor from ...
Alesia Ivashkevich, Alesia Ivashkevich
doaj   +1 more source

AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells [PDF]

Journal of the Serbian Chemical Society, 2005
Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells.
Avramov-Ivić M., Petrović Slobodan D., Kalman E., Milosavljević T., Reljin I., Reljin B., Bogdanović G., Baltić Vit.V., Keresztes Z.   +8 more
doaj   +1 more source

Loss of TOP3B leads to increased R-loop formation and genome instability [PDF]

Open Biology, 2019
Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease.
Tao Zhang, Mathew Wallis, Vida Petrovic, Jackie Challis, Paul Kalitsis, Damien F. Hudson   +5 more
doaj   +1 more source

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function

eLife, 2022
Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong, Joyce H Lee, Claudia C Carcamo, Matthew W Parker, James M Berger   +4 more
doaj   +1 more source

DNA-Binding Anticancer Drugs: One Target, Two Actions

Molecules, 2021
Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acute ...
Bruce C. Baguley, Catherine J. Drummond, Ying Yi Chen, Graeme J. Finlay   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas

Molecules, 2018
A series of 2-(1H-indol-3-yl)ethylthiourea derivatives were prepared by condensation of 2-(1H-indol-3-yl)ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media.
Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Sandra Piras, Marta Struga, Małgorzata Wrzosek, Grażyna Kubiak-Tomaszewska, Anna E. Koziol, Oleksandra Savchenko, Tadeusz Lis, Joanna Stefanska, Piotr Tomaszewski, Michał Skrzycki, Daniel Szulczyk   +13 more
doaj   +1 more source

Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities

Antibiotics, 2017
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death.
Temilolu Idowu, Frank Schweizer
doaj   +1 more source