Results 1 to 10 of about 146,411 (237)

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]

Biology Open, 2012
Summary Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions ...
Ka Cheong Lee, Kay Padget, Hannah Curtis, Ian G. Cowell, Davide Moiani, Zbyslaw Sondka, Nicholas J. Morris, Graham H. Jackson, Simon J. Cockell, John A. Tainer, Caroline A. Austin   +10 more
doaj   +5 more sources

How enzymatic activity is involved in chromatin organization

eLife, 2022
Spatial organization of chromatin plays a critical role in genome regulation. Previously, various types of affinity mediators and enzymes have been attributed to regulate spatial organization of chromatin from a thermodynamics perspective.
Rakesh Das, Takahiro Sakaue, GV Shivashankar, Jacques Prost, Tetsuya Hiraiwa   +4 more
doaj   +1 more source

BLM and RMI1 alleviate RPA inhibition of topoIIIα decatenase activity [PDF]

, 2012
RPA is a single-stranded DNA binding protein that physically associates with the BLM complex. RPA stimulates BLM helicase activity as well as the double Holliday junction dissolution activity of the BLM-topoisomerase IIIα complex.
A Bochkarev, A Machwe, AR Meetei, C Iftode, CF Chen, Csanad Z. Bachrati, CZ Bachrati, D Sikder, D Xu, Grant W. Brown, H Goulaouic, Ian D. Hickson, ID Hickson, J Yang, J Yin, Jay Yang, JJ Champoux, JL Plank, JL Plank, K Kirkegaard, KM Doherty, L Wu, L Wu, MP Fairman, MS Wold, MS Wold, NA Desai, NA Ellis, P Cejka, P Mohaghegh, PL Garcia, RM Brosh Jr, RS Chaganti, S Raynard, S Raynard, S Sharma, Sergey Korolev, T Wechsler, Y Liu, Y Zou   +39 more
core   +8 more sources

The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity

Life, 2022
Aeroplysinin-1 is a brominated isoxazoline alkaloid that has exhibited a potent antitumor cell effect in previous reports. We evaluated the cytotoxicity of aeroplysinin-1 against leukemia and prostate cancer cells in vitro. This marine alkaloid inhibited
Shou-Ping Shih, Mei-Chin Lu, Mohamed El-Shazly, Yu-Hsuan Lin, Chun-Lin Chen, Steve Sheng-Fa Yu, Yi-Chang Liu   +6 more
doaj   +1 more source

Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity

Pathogens, 2021
In the last few years, increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory.
Iwona Gabriel, Kamila Rząd, Ewa Paluszkiewicz, Katarzyna Kozłowska-Tylingo   +3 more
doaj   +1 more source

Topoisomerase Assays [PDF]

Current Protocols in Pharmacology, 2012
AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and pass double‐stranded DNA. DNA topoisomerases are important targets
John L, Nitiss, Eroica, Soans, Anna, Rogojina, Aman, Seth, Margarita, Mishina   +4 more
openaire   +2 more sources

The role of isoflavones in augmenting the effects of radiotherapy

Frontiers in Oncology, 2023
Cancer is one of the major health problems and the second cause of death worldwide behind heart disease. The traditional soy diet containing isoflavones, consumed by the Asian population in China and Japan has been identified as a protective factor from ...
Alesia Ivashkevich, Alesia Ivashkevich
doaj   +1 more source

AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells [PDF]

Journal of the Serbian Chemical Society, 2005
Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells.
Avramov-Ivić M., Petrović Slobodan D., Kalman E., Milosavljević T., Reljin I., Reljin B., Bogdanović G., Baltić Vit.V., Keresztes Z.   +8 more
doaj   +1 more source

Loss of TOP3B leads to increased R-loop formation and genome instability [PDF]

Open Biology, 2019
Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease.
Tao Zhang, Mathew Wallis, Vida Petrovic, Jackie Challis, Paul Kalitsis, Damien F. Hudson   +5 more
doaj   +1 more source

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function

eLife, 2022
Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong, Joyce H Lee, Claudia C Carcamo, Matthew W Parker, James M Berger   +4 more
doaj   +1 more source