Results 21 to 30 of about 68,974 (263)
AN INSIGHT INTO MEDICINAL PROPERTIES OF QUINOXALINE SCAFFOLD, WITH A FOCUS ON THEIR ANTICANCER POTENTIAL AS INTERCALATING AGENTS [PDF]
Al-Azhar Journal of Pharmaceutical SciencesThe antitumor properties of synthetic heterocyclic compounds are among the most important properties that can be made use in medicinal chemistry. More specifically, their significant cytotoxic effects against many types of human tumor cells, as well as ...
Mohammed Dahab +3 more
doaj +1 more source
Pharmaceuticals, 2023 Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman +2 more
doaj +1 more source
Topoisomerases in kinetoplastids
Parasitology Today, 1996 Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes.
C, Burri, A L, Bodley, T A, Shapiro
openaire +2 more sources
AFM studies of DNA structures extracted from adriamycin treated and non-treated Ehrlich tumor cells [PDF]
Journal of the Serbian Chemical Society, 2005 Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells.
M. AVRAMOV IVIC +8 more
doaj
Marine Drugs, 2014 A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells.
Huei-Chuan Shih +9 more
doaj +1 more source
Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life
CellsTopoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj +1 more source
EMBO Molecular Medicine, 2012 Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti‐leishmanial agent.
Sayan Chowdhury +8 more
doaj +1 more source
Type IA Topoisomerases as Targets for Infectious Disease Treatments
Microorganisms, 2021 Infectious diseases are one of the main causes of death all over the world, with antimicrobial resistance presenting a great challenge. New antibiotics need to be developed to provide therapeutic treatment options, requiring novel drug targets to be ...
Ahmed Seddek +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Química Nova, 2012 Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA.
Amanda de Melo Bezerra +8 more
doaj +1 more source