Results 21 to 30 of about 146,499 (323)

Dynamics of chromosome organization in a minimal bacterial cell

Frontiers in Cell and Developmental Biology, 2023
Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material.
Benjamin R. Gilbert, Zane R. Thornburg, Troy A. Brier, Jan A. Stevens, Fabian Grünewald, John E. Stone, John E. Stone, Siewert J. Marrink, Zaida Luthey-Schulten, Zaida Luthey-Schulten, Zaida Luthey-Schulten   +10 more
doaj   +1 more source

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 [PDF]

, 2007
DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs).
Arnaudeau, Avemann, Barzilai, Bendixen, Caldecott, Caldecott, Cheng, Chrencik, Christiansen, Clements, Connelly, Culmsee, Daroui, Date, Davies, Davies, Davies, de Boer, Deng, D’Arpa, El-Khamisy, Flangas, Furuta, Godthelp, Hinz, Holm, Horwitz, Hsiang, Inamdar, Interthal, Interthal, Interthal, K.W. Caldecott, Kroeger, Lanza, Lesher, Liao, Lindahl, Liu, Mol, Moreira, Morris, Nitiss, Nouspikel, O’Driscoll, Parsons, Plo, Pommier, Pommier, Pommier, Poot, Pouliot, Pouliot, Pourquier, Pourquier, Pourquier, Pourquier, Pourquier, Rideout, Ryan, Ryan, S.F. El-Khamisy, Sarkander, Sarkander, Shao, Stewart, Strumberg, Takashima, Taylor, Thompson, van Waardenburg, Vance, Vidal, Vierck, Wang, Whitehouse, Wilson, Wu, Wu, Yan, Yang, Zhou, Zhou   +82 more
core   +1 more source

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source

THE ROLE OF EFFLUX PUMP AND OTHER MECHANISMS OF ANTIMICROBIAL RESISTANCE TO (FLUORO)QUINOLONES IN EPIDEMIC ISOLATES OF SALMONELLA TYPHIMURIUM, SALMONELLA KENTUCKY AND SALMONELLA INFANTIS

Archives of Veterinary Medicine, 2015
This paper briefly describes mechanisms of resistance to fluoroquinolones in several worldwide distributed Salmonella clones. The isolates have acquired multiple resistance traits over the years due to extensive antibiotic treatment both in human and ...
Marina Arnaut, Maja Velhner, Ljiljana Suvajdžić, Dubravka Milanov, Jelena Petrović, Gordana Kozoderović   +5 more
doaj   +1 more source

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability [PDF]

, 2015
Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA
Anna L. Chambers, Hiasa, Jessica A. Downs, Jonathan Baxter, Sahar Mansoubi, Stephanie A. Schalbetter   +5 more
core   +3 more sources

Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

eLife, 2022
Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by 12 tandem (HhH)2 domains, which include 3 AP lyase repair domains.
Amy Osterman, Alfonso Mondragón
doaj   +1 more source

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]

, 2020
The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina, Cortés Ledesma, Felipe, Delgado Sainz, Irene, García Quintanilla, Lourdes, Jimeno González, Silvia, Martínez García, Pedro Manuel, Quintero, Cristina, Romero Granados, Rocío, Serrano Benítez, Almudena, Terrón Bautista, José, Álvarez Quilón, Alejandro   +10 more
core   +3 more sources

Amsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M. smegmatis Growth and Disturb Chromosome Replication

Frontiers in Microbiology, 2018
Amsacrine, which inhibits eukaryotic type II topoisomerase via DNA intercalation and stabilization of the cleavable topoisomerase-DNA complex, promotes DNA damage and eventually cell death.
Marcin J. Szafran, Marta Kołodziej, Patrycja Skut, Brahmam Medapi, Agnieszka Domagała, Damian Trojanowski, Jolanta Zakrzewska-Czerwińska, Jolanta Zakrzewska-Czerwińska, Dharmarajan Sriram, Dagmara Jakimowicz, Dagmara Jakimowicz   +10 more
doaj   +1 more source

Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1

Pharmaceutics, 2021
Background: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently, compounds that inhibit topoisomerase 1 activity may be of interest.
Kamilla Vandsø Petersen, Asier Selas, Kirstine Mejlstrup Hymøller, Karol Mizielinski, Maria Thorsager, Magnus Stougaard, Concepcion Alonso, Francisco Palacios, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Cinzia Tesauro   +12 more
doaj   +1 more source