Results 11 to 20 of about 68,974 (263)
Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells [PDF]
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari +7 more
wiley +2 more sources
Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas
Molecules, 2018 A series of 2-(1H-indol-3-yl)ethylthiourea derivatives were prepared by condensation of 2-(1H-indol-3-yl)ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media.
Giuseppina Sanna +13 more
doaj +1 more source
Antibiotics, 2017 Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death.
Temilolu Idowu, Frank Schweizer
doaj +1 more source
Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents
Pharmaceuticals, 2023 Topoisomerases are very important enzymes that regulate DNA topology and are vital for biological actions like DNA replication, transcription, and repair. The emergence and spread of cancer has been intimately associated with topoisomerase dysregulation.
Prasanna Anjaneyulu Yakkala +3 more
doaj +1 more source
Knowledge and Management of Aquatic Ecosystems, 2004 A comparative study of topoisomerase activity in two European crayfish species Astacus astacus and Austropotamobius pallipes was carried out to determine the physiological basis of the difference in ecological fitness of these systematically related ...
PAOLUCCI M. +3 more
doaj +1 more source
Dynamics of chromosome organization in a minimal bacterial cell
Frontiers in Cell and Developmental Biology, 2023 Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material.
Benjamin R. Gilbert +10 more
doaj +1 more source
Archives of Veterinary Medicine, 2015 This paper briefly describes mechanisms of resistance to fluoroquinolones in several worldwide distributed Salmonella clones. The isolates have acquired multiple resistance traits over the years due to extensive antibiotic treatment both in human and ...
Marina Arnaut +5 more
doaj +1 more source
Frontiers in Microbiology, 2018 Amsacrine, which inhibits eukaryotic type II topoisomerase via DNA intercalation and stabilization of the cleavable topoisomerase-DNA complex, promotes DNA damage and eventually cell death.
Marcin J. Szafran +10 more
doaj +1 more source
eLife, 2022 Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by 12 tandem (HhH)2 domains, which include 3 AP lyase repair domains.
Amy Osterman, Alfonso Mondragón
doaj +1 more source
Pharmaceutics, 2021 Background: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently, compounds that inhibit topoisomerase 1 activity may be of interest.
Kamilla Vandsø Petersen +12 more
doaj +1 more source