Results 31 to 40 of about 146,499 (323)

Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons. [PDF]

, 2016
Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits.
Butchbach, Matthew E.R., Gentillon, Cinsley, Harris, Ashlee W., Holbrook, Jennifer, Lumpkin, Casey J., McCahan, Suzanne M., Rossi, Sharyn L., Wang, Wenlan   +7 more
core   +2 more sources

Critical concepts, practice recommendations, and research perspectives of pixantrone therapy in non-Hodgkin lymphoma: a SIE, SIES, and GITMO consensus paper [PDF]

, 2016
Objectives: In this paper, we present a review of critical concepts and research perspectives and produce recommendations on the optimal use of pixantrone in non-Hodgkin lymphoma (NHL) by group discussion from an expert panel appointed by the Italian ...
Barosi, Giovanni, Corradini, Paolo, Martelli, Maurizio, Minotti, Giorgio, Oliva, Stefano, Spina, Michele, Tura, Sante, Zinzani, Pier Luigi   +7 more
core   +1 more source

Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

Marine Drugs, 2014
A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells.
Huei-Chuan Shih, Mohamed El-Shazly, Yung-Shun Juan, Chao-Yuan Chang, Jui-Hsin Su, Yu-Cheng Chen, Shou-Ping Shih, Huei-Mei Chen, Yang-Chang Wu, Mei-Chin Lu   +9 more
doaj   +1 more source

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Pharmaceuticals, 2023
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie   +2 more
doaj   +1 more source

Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients [PDF]

, 2016
Objective: Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in
Crea, F., Danesi, R., De Gregorio, V., Falcone, A., Fornaro, L., Graziano, F., Loupakis, F., Masi, G., Paolicchi, E., Ricci, V., Ronzoni, M., Vivaldi, C.   +11 more
core   +1 more source

AFM studies of DNA structures extracted from adriamycin treated and non-treated Ehrlich tumor cells [PDF]

Journal of the Serbian Chemical Society, 2005
Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells.
M. AVRAMOV IVIC, S. D. PETROVIC, E. KALMÁN, T. MILOSAVLJEVIC, I. RELJIN, B. RELJIN, G. BOGDANOVIC, V. VIT. BALTIC, Z. KERESZTES   +8 more
doaj  

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the identification of a natural compound, membranoid G, derived from the Antarctic sponge Dendrilla antarctica displaying an in 
Alessio Ottaviani, Joshua Welsch, Keli Agama, Yves Pommier, Alessandro Desideri, Bill J. Baker, Paola Fiorani   +6 more
doaj   +1 more source

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Cells
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +2 more sources

The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice

EMBO Molecular Medicine, 2012
Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti‐leishmanial agent.
Sayan Chowdhury, Tulika Mukherjee, Rupkatha Mukhopadhyay, Budhaditya Mukherjee, Souvik Sengupta, Sharmila Chattopadhyay, Parasuraman Jaisankar, Syamal Roy, Hemanta K. Majumder   +8 more
doaj   +1 more source