Results 31 to 40 of about 90,099 (199)

AN INSIGHT INTO MEDICINAL PROPERTIES OF QUINOXALINE SCAFFOLD, WITH A FOCUS ON THEIR ANTICANCER POTENTIAL AS INTERCALATING AGENTS [PDF]

Al-Azhar Journal of Pharmaceutical Sciences
The antitumor properties of synthetic heterocyclic compounds are among the most important properties that can be made use in medicinal chemistry. More specifically, their significant cytotoxic effects against many types of human tumor cells, as well as ...
Mohammed Dahab, Mohammed Abdel Hamid, Ibrahim Eissaa, Mohammed Mohammed   +3 more
doaj   +1 more source

A role for topoisomerase II alpha in chromosome damage in human cell lines [PDF]

, 2010
Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations.
Terry, Samantha Y.A.
core   +2 more sources

AFM studies of DNA structures extracted from adriamycin treated and non-treated Ehrlich tumor cells [PDF]

Journal of the Serbian Chemical Society, 2005
Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells.
M. AVRAMOV IVIC, S. D. PETROVIC, E. KALMÁN, T. MILOSAVLJEVIC, I. RELJIN, B. RELJIN, G. BOGDANOVIC, V. VIT. BALTIC, Z. KERESZTES   +8 more
doaj  

Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

Marine Drugs, 2014
A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells.
Huei-Chuan Shih, Mohamed El-Shazly, Yung-Shun Juan, Chao-Yuan Chang, Jui-Hsin Su, Yu-Cheng Chen, Shou-Ping Shih, Huei-Mei Chen, Yang-Chang Wu, Mei-Chin Lu   +9 more
doaj   +1 more source

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Pharmaceuticals, 2023
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie   +2 more
doaj   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Yuh-Hwa Wang (457429), Dillon, LW, Yuh-Hwa Wang, Christine E. Lehman (457427), Laura W Dillon, Dillon Laura W., Nikiforov Yuri E., Pierce Levi C. T., Wang, YH, Laura W. Dillon (457426), Lehman, Christine E., Christine E Lehman, Lehman, CE, Pierce, Levi C. T., Nikiforov, Yuri E., Pierce, LCT, Yuri E. Nikiforov (457428), Levi C T Pierce, Rybenkov, Valentin V, Wang, Yuh-Hwa, Wang Yuh-Hwa, Levi C. T. Pierce (454414), Lehman Christine E., Yuri E Nikiforov, Dillon, Laura W., Nikiforov, YE   +25 more
core   +2 more sources

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Cells
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj   +1 more source

The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice

EMBO Molecular Medicine, 2012
Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti‐leishmanial agent.
Sayan Chowdhury, Tulika Mukherjee, Rupkatha Mukhopadhyay, Budhaditya Mukherjee, Souvik Sengupta, Sharmila Chattopadhyay, Parasuraman Jaisankar, Syamal Roy, Hemanta K. Majumder   +8 more
doaj   +1 more source

The impact of the human DNA topoisomerase II C-terminal domain on activity [PDF]

, 2008
Background Type II DNA topoisomerases (topos) are essential enzymes needed for the resolution of topological problems that occur during DNA metabolic processes.
West, K.L., Katherine L West, Meczes, E.L., Kathryn L Gilroy, Caroline A Austin, Austin Caroline A., Austin, C.A., Gilroy Kathryn L., Meczes Emma L., Gilroy, K.L., Emma L Meczes, West Katherine L.   +11 more
core   +2 more sources

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]

, 2007
BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher, Nilsson, D,, Nilsson, Daniel, Andersson, B,, Andersson, Bjorn, Bot, C,, Obado, SO, Obado, Samson O, Kelly, JM, Kelly, John M   +9 more
core   +1 more source