Results 51 to 60 of about 90,099 (199)

The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence

Diseases, 2017
Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions.
Khaled A. Selim, Hend Abdelrasoul, Mohamed Aboelmagd, Ahmed M. Tawila   +3 more
doaj   +1 more source

A RADAR-Based Assay to Isolate Covalent DNA Complexes in Bacteria

Antibiotics, 2019
Quinolone antibacterials target the type II topoisomerases gyrase and topoisomerase IV and kill bacterial cells by converting these essential enzymes into cellular poisons. Although much is known regarding the interactions between these drugs and enzymes
Katie J. Aldred, Adeline Payne, Olivia Voegerl   +2 more
doaj   +1 more source

Resistance rate and mechanism of ureaplasma urealyticum to fluoroquinolones in infertile patients

陆军军医大学学报, 2022
Objective To investigate the resistance of ureaplasma urealyticum (Uu) isolated from infertile patients to fluoroquinolones, and explore the correlation between quinolone resistance determining regions (QRDR) mutations in topoisomerase gene and ...
YUAN Yaling1, YUAN Yaling1, XIA Yun
doaj   +1 more source

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

eLife, 2019
Ribosome biogenesis is a complex and energy-demanding process requiring tight coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production.
Benjamin Albert, Isabelle C Kos-Braun, Anthony K Henras, Christophe Dez, Maria Paula Rueda, Xu Zhang, Olivier Gadal, Martin Kos, David Shore   +8 more
doaj   +1 more source

Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold [PDF]

, 2019
A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkaloid ...
Iwao, Masatomo, Fujimoto, Masahiro, Ishibashi, Fumito, Okazaki, Fumiyasu, Nanjo, Yusuke, Yoshida, Kenyu, Fukuda, Tsutomu, Natsui, Yuko, To, Hideto   +8 more
core   +1 more source

Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Thiazolopyrimidinium systems with a quaternized nitrogen atom are attracting increasing attention in the development of new anticancer drugs. Their unique chemical structure and potential biological properties make them promising candidates for the ...
B. V. Paponov, O. S. Shemchuk, D. N. Maistrenko, O. E. Molchanov, V. V. Sharoyko, K. N. Semenov   +5 more
doaj   +1 more source

A Support Vector Machine Classification Model for Benzo[c]phenathridine Analogues with Topoisomerase-I Inhibitory Activity

Molecules, 2012
Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, a support vector machine model was performed on a series of 73 analogues to classify BCP derivatives ...
Thanh-Dao Tran, Thi-Ngoc-Phuong Huynh, Thuy-Quyen Nguyen, Trieu-Du Ngo, Khac-Minh Thai   +4 more
doaj   +1 more source

Transcriptome Reprogramming of Symbiodiniaceae Breviolum minutum in Response to Casein Amino Acids Supplementation

Frontiers in Physiology, 2020
Dinoflagellates in the family Symbiodiniaceae can live freely in ocean waters or form a symbiosis with a variety of cnidarians including corals, sea anemones, and jellyfish.
Andrea L. Kirk, Sophie Clowez, Fan Lin, Arthur R. Grossman, Tingting Xiang   +4 more
doaj   +1 more source

In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II

Pharmaceuticals
Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their
Mohamed Badr, Elshaymaa I. Elmongy, Doaa Elkhateeb, Yasmine S. Moemen, Ashraf Khalil, Hadeer Ali, Reem Binsuwaidan, Feby Awadallah, Ibrahim El Tantawy El Sayed   +8 more
doaj   +1 more source

Dietary topoisomerase II-poisons [PDF]

, 2002
DNA topoisomerases are nuclear enzymes inducing transient breaks in the DNA allowing DNA strands or double helices to pass through each other. The clinically used DNA topoisomerase II-poison etoposide is known to induce DNA double strand breaks leading ...
Oesch, Franz, Tanner, Berno, Gebhard, Susanne, Bolt, Hermann M., Heimerdinger, Carolin K., Schiffer, Ilka B., Hengstler, Jan G., Sagemüller, Jens   +7 more
core   +1 more source