Results 61 to 70 of about 90,099 (199)
GSVA analysis of topoisomerase family genes.
, 2022 (A) Differences of topoisomerase score in paraneoplastic and tumor tissues. The topoisomerase score represents the integrated level of the expression of topoisomerase family genes, which is positively correlated with gene expression.
Guanghao Li (2888015) +5 more
core +1 more source
Emerging Infectious Diseases, 2003 Clinical antimicrobial susceptibility breakpoints are used to predict the clinical outcome of antimicrobial treatment. In contrast, microbiologic breakpoints are used to identify isolates that may be categorized as susceptible when applying clinical ...
Sue Lim +4 more
doaj +1 more source
Spinocerebellar ataxia with axonal neuropathy:consequence of a Tdp1 recessive neomorphic mutation? [PDF]
, 2007 Tyrosyl-DNA phosphodiesterase 1 (Tdp1) cleaves the phosphodiester bond between a covalently stalled topoisomerase I (Topo I) and the 3' end of DNA.
Choi, Kunho +16 more
core +1 more source
Poly(ADP-Ribose) Polymerase (PARP) signaling of DNA damage induced by Topoisomerase 1 (TOP1) inhibition in carcinoma cells: chemotherapeutic implications of PARP and TOP1 inhibitors. [PDF]
, 2010 Una nuova strategia molecolare che incrementa l’azione antitumorale degli inibitori della Topoisomerasi 1 (TOP1) si basa sull’utilizzo di inibitori delle poli(ADP-ribosio) polimerasi (PARP).
D'Onofrio, Giovanna
core +1 more source
Protein-protein Interactions of Bacterial Topoisomerase I [PDF]
, 2017 Protein-protein interactions (PPIs) are essential features of cellular processes including DNA replication, transcription, translation, recombination, and repair. In my study, the protein interactions of bacterial DNA topoisomerase I, an essential enzyme,
Banda, Srikanth
core +1 more source
Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide
Journal of Nucleic Acids, 2010 The role of topoisomerase IIβ was investigated in cell lines exposed to two DNA damaging agents, ionising radiation (IR) or etoposide, a drug which acts on topoisomerase II. The appearance and resolution of γH2AX foci in murine embryonic fibroblast cell
Nicola J. Sunter +4 more
doaj +1 more source
, 2009 The genes encoding the subunits of DNA topoisomerase IV (parC and parE) and DNA gyrase (gyrA and gyrB) of Streptococcus pneumoniae were cloned and overproduced in Escherichia coli by using the T7promoter-T7 RNA polymerase system.
Balas, Delia +3 more
core +1 more source
Molecules, 2016 Topoisomerases have been shown to have roles in cancer progression. Here, we have examined the effect of cryptolepine, a plant alkaloid, on the growth of human non-melanoma skin cancer cells (NMSCC) and underlying mechanism of action.
Harish C. Pal, Santosh K. Katiyar
doaj +1 more source
Evolutionary twist on topoisomerases: Conversion of gyrase to topoisomerase IV [PDF]
Proceedings of the National Academy of Sciences, 2010 Type II topoisomerases are essential enzymes found in all cells, where they maintain the topology of DNA in a well-defined state (1). The defining activity of type II topoisomerases is an ATP-dependent passage of a segment of dsDNA through a transient double-stranded break in a second segment of dsDNA (Fig. 1) (1, 2).
openaire +2 more sources
Topoisomerase activity assays in Neurospora [PDF]
, 1989 DNA topoisomerases are enzymes capable of altering the topological conformation of DNA by inducing transient single (Topoisomerase I) and double strand (Topoisomerase II ...
Bohnet, S. +5 more
core +1 more source