Results 1 to 10 of about 17,370 (252)
Substrate binding of human and bacterial type IA topoisomerase: An experimentation with AlphaFold 3.0 [PDF]
Computational and Structural Biotechnology JournalAdvancements in biophysical techniques such as X-ray crystallography and Cryo-EM have allowed the determination of three-dimensional structures of many proteins and nucleic acids.
Yasir Mamun +11 more
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Molecular Docking for the Development of Alternative Therapies against Leishmaniasis
Chemistry Proceedings, 2023 Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata +3 more
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Biology, 2021 DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined.
Jorge Cebrián +5 more
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Topological Process of Splitting DNA-Links
Biomath, 2022 A DNA replicon is modeled by a special type of 2-component link, called a DNA-link, in which two circles form a double helix around a trivial center core curve.
Abdul Adheem Mohamad, Tsukasa Yashiro
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Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds
Pharmaceuticals, 2023 With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary.
Josephine Geertsen Keller +12 more
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Type IA Topoisomerases as Targets for Infectious Disease Treatments
Microorganisms, 2021 Infectious diseases are one of the main causes of death all over the world, with antimicrobial resistance presenting a great challenge. New antibiotics need to be developed to provide therapeutic treatment options, requiring novel drug targets to be ...
Ahmed Seddek +2 more
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SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases
Frontiers in Molecular Biosciences, 2022 Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA structures arising in double-stranded DNA.
Yilun Sun, John L. Nitiss, Yves Pommier
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BLM and RMI1 alleviate RPA inhibition of topoIIIα decatenase activity [PDF]
, 2012 RPA is a single-stranded DNA binding protein that physically associates with the BLM complex. RPA stimulates BLM helicase activity as well as the double Holliday junction dissolution activity of the BLM-topoisomerase IIIα complex.
A Bochkarev +39 more
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Antibiotics, 2023 Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibacterial agents that target bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Our recently disclosed crystal structure of an NBTI ligand in complex with DNA gyrase
Maja Kokot +5 more
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Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase. [PDF]
PLoS Genetics, 2017 Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind
Wareed Ahmed +5 more
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