Results 1 to 10 of about 577,305 (203)
Recombination in Eukaryotic Single Stranded DNA Viruses [PDF]
Viruses, 2011 Although single stranded (ss) DNA viruses that infect humans and their domesticated animals do not generally cause major diseases, the arthropod borne ssDNA viruses of plants do, and as a result seriously constrain food production in most temperate ...
Philippe Roumagnac +5 more
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End-repair causes methylation underestimation in cell-free DNA sequencing libraries [PDF]
The Journal of Liquid BiopsyCell-free DNA methylation sequencing provides insight into tissue of origin and chromatin structure. In some workflows, generating libraries includes end-repair.
Tobin E. Groth +4 more
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Methods and Protocols, 2021 After a DNA double-strand break, cells utilize either non-homologous end joining or homologous recombination to repair the broken DNA ends. Homologous recombination requires extensive nucleolytic processing of one of the DNA strands, resulting in long ...
Faith C. Fowler, Jessica K. Tyler
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Biomolecules, 2022 Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome stability by protecting the transient existence of ssDNA from damage during essential biological processes, such as DNA replication and gene transcription.
Jun-Tao Guo, Fareeha Malik
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Sensors, 2021 The performance of a biosensor is associated with the properties of an immobilization layer on a sensor chip. In this study, gold sensor chips were modified with two different immobilization layers, polytyramine film and 6-mercaptohexanol self-assembled ...
Ally Mahadhy +3 more
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Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA
iScience, 2022 Summary: Plasma cell-free DNA is being widely explored as a biomarker for clinical screening. Currently, methods are optimized for the extraction and detection of double-stranded mononucleosomal cell-free DNA of ∼160bp in length. We introduce uscfDNA-seq,
Jordan Cheng +13 more
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Single Stranded DNA Translocases can Push Single Stranded DNA Binding Proteins along Single Stranded DNA [PDF]
Biophysical Journal, 2016 Single-stranded (ss) DNA binding proteins (SSBs) protect ssDNA intermediates during genome maintenance. These SSBs must eventually be displaced or reorganized and one potential mechanism for reorganization is pushing of the SSB along the DNA by ssDNA translocases (ATP-dependent motors).
Sokoloski, Joshua E. +3 more
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Single-stranded circular DNA theranostics
Theranostics, 2022 The past decade has witnessed the blossom of nucleic acid therapeutics and diagnostics (theranostics). Unlike conventional small molecule medicines or protein biologics, nucleic acid theranostics have characteristic features such as the intrinsic ability as "information drugs" to code and execute genetic and theranostic information, ready ...
Shen, Tingting +4 more
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Fluorescent single-stranded DNA-binding protein from Plasmodium falciparum as a biosensor for single-stranded DNA. [PDF]
PLoS ONE, 2018 Single-stranded DNA (ssDNA) is a product of many cellular processes that involve double-stranded DNA, for example during DNA replication and repair, and is formed transiently in many others. Measurement of ssDNA formation is fundamental for understanding
Liisa T Chisty +2 more
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CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential
Nature Communications, 2023 Genomic DNA (gDNA) undergoes structural interconversion between single- and double-stranded states during transcription, DNA repair and replication, which is critical for cellular homeostasis.
Youtao Lu +18 more
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