Results 1 to 10 of about 53,634 (224)
Turkish Journal of Agriculture: Food Science and TechnologyThis study presents a comprehensive investigation into the interactions of two distinct synthetic dyes—1,9-Dimethyl-Methylene Blue and Toluidine Blue —with different DNA structures, namely calf thymus DNA (ct-DNA), G-quadruplex DNA, and single stranded ...
Efkan Bağda, Didem Duman
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Bioengineering, 2022 Poly(ethylene glycol) (PEG) films, fabricated by thermally induced crosslinking of amine- and epoxy-terminated four-arm STAR-PEG precursors, were used as porous and bioinert matrix for single-stranded DNA (ssDNA) immobilization and hybridization.
Zhiyong Zhao +2 more
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Coordinated Binding of Single-Stranded and Double-Stranded DNA by UvsX Recombinase. [PDF]
PLoS ONE, 2013 Homologous recombination is important for the error-free repair of DNA double-strand breaks and for replication fork restart. Recombinases of the RecA/Rad51 family perform the central catalytic role in this process.
Robyn L Maher, Scott W Morrical
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PLoS ONE, 2023 Human Replication Protein A (hRPA) is a multidomain protein that interacts with ssDNA intermediates to provide the latter much-needed stability during DNA metabolism and maintain genomic integrity.
Sangeeta, Arnab Bhattacherjee
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Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. [PDF]
PLoS Genetics, 2012 Antibody diversification necessitates targeted mutation of regions within the immunoglobulin locus by activation-induced cytidine deaminase (AID). While AID is known to act on single-stranded DNA (ssDNA), the source, structure, and distribution of these ...
Jahan-Yar Parsa +8 more
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eLife, 2023 Cells have evolved the DNA damage response (DDR) pathways in response to DNA replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed that ATR is recruited to RPA-coated single-stranded DNA (ssDNA) by direct ATRIP-RPA ...
Yunfeng Lin +5 more
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Construction of ssDNA-Attached LR-Chimera Involving Z-DNA for ZBP1 Binding Analysis
Molecules, 2022 The binding of proteins to Z-DNA is hard to analyze, especially for short non-modified DNA, because it is easily transferred to B-DNA. Here, by the hybridization of a larger circular single-stranded DNA (ssDNA) with a smaller one, an LR-chimera ...
Lin Li, Ran An, Xingguo Liang
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Managing Single-Stranded DNA during Replication Stress in Fission Yeast
Biomolecules, 2015 Replication fork stalling generates a variety of responses, most of which cause an increase in single-stranded DNA. ssDNA is a primary signal of replication distress that activates cellular checkpoints. It is also a potential source of genome instability
Sarah A. Sabatinos, Susan L. Forsburg
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Archaeal Orc1 protein interacts with T-rich single-stranded DNA
BMC Research Notes, 2021 Objective The ability to form nucleoprotein complexes is a fundamental activity of DNA replication initiation proteins. They bind within or nearby the region of replication origin what results in melting of a double-stranded DNA (dsDNA) and formation of ...
Katarzyna Wegrzyn, Igor Konieczny
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Nature Communications, 2023 Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA tumor suppressor pathway.
Anastasia Hale +4 more
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