Results 1 to 10 of about 53,752 (247)
A Label-Free, Mix-and-Detect ssDNA-Binding Assay Based on Cationic Conjugated Polymers
Biosensors, 2023 The accurate, simple, and efficient measurement of the concentration of single-stranded DNA (ssDNA) is important for many analytical applications, such as DNA adsorption, biosensor design, and disease diagnosis, but it is still a challenge.
Juewen Liu +2 more
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An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast [PDF]
Frontiers in MicrobiologySingle-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami +8 more
doaj +2 more sources
Development of a novel, high-affinity ssDNA trypsin inhibitor
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we developed a family of novel ...
Piotr Mydel +2 more
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Systematic Selection of High‐Affinity ssDNA Sequences to Carbon Nanotubes
Advanced ScienceSingle‐walled carbon nanotubes (SWCNTs) have gained significant interest for their potential in biomedicine and nanoelectronics. The functionalization of SWCNTs with single‐stranded DNA (ssDNA) enables the precise control of SWCNT alignment and the ...
Sanghwa Jeong, Dakyeon Lee
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A comparative study of protein–ssDNA interactions [PDF]
NAR Genomics and Bioinformatics, 2021 Abstract Single-stranded DNA-binding proteins (SSBs) play crucial roles in DNA replication, recombination and repair, and serve as key players in the maintenance of genomic stability. While a number of SSBs bind single-stranded DNA (ssDNA) non-specifically, the others recognize and bind specific ssDNA sequences. The mechanisms underlying
Maoxuan Lin +2 more
openaire +2 more sources
Nanomaterials, 2020 The metabolic activity in plants or fruits is associated with volatile organic compounds (VOCs), which can help identify the different diseases. P-ethylphenol has been demonstrated as one of the most important VOCs released by the Phytophthora cactorum ...
Hui Wang +3 more
doaj +1 more source
VirE2: a unique ssDNA-compacting molecular machine. [PDF]
PLoS Biology, 2008 The translocation of single-stranded DNA (ssDNA) across membranes of two cells is a fundamental biological process occurring in both bacterial conjugation and Agrobacterium pathogenesis.
Wilfried Grange +5 more
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Expression of ssDNA in Mammalian Cells [PDF]
BioTechniques, 2003 Antisense therapy involves the use of antisense oligonucleotides for altering targeted gene function. However, the low efficiency of cell delivery of antisense oligonucleotides has limited the efficacy of antisense therapeutic approaches. RNA-based antisense or ribozyme oligonucleotides can be either synthesized endogenously (e.g., by a viral vector ...
Yin Chen, Yong-Jie Ji, Charles Conrad
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Acta Medica, 2020 A significant population of ultrashort (50–150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL−1), but not in plasma of healthy donors.
Kirill V. Ermakov +5 more
doaj +1 more source
ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
Nature Communications, 2023 The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA) plays a crucial role in various DNA metabolic pathways, including DNA replication and repair, by dynamically associating with ssDNA.
Jiawei Ding +7 more
doaj +1 more source