Results 21 to 30 of about 578,618 (302)
UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
Nature Communications, 2021 R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role
Greg H. P. Ngo +2 more
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Continuous Approximation for Interaction Energy Transfer of DNA through Lipid Bilayers
Discrete Dynamics in Nature and Society, 2018 In this study the interaction energies for single-stranded DNA and double-stranded DNA molecules with a lipid bilayer are investigated. The 6-12 Lennard-Jones potential and continuous approximation are used to derive analytical expressions for these ...
Mansoor H. Alshehri
doaj +1 more source
Proceedings, 2020 Single-stranded DNA binding proteins (SSBs) bind to single-stranded DNA in a sequence-independent manner to prevent formation of secondary structures and protect DNA from nuclease degradation.
Olesia Werbowy +9 more
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Direct imaging of single UvrD helicase dynamics on long single-stranded DNA [PDF]
, 2013 Fluorescence imaging of single-protein dynamics on DNA has been largely limited to double-stranded DNA or short single-stranded DNA. We have developed a hybrid approach for observing single proteins moving on laterally stretched kilobase-sized ssDNA ...
Balci, Hamza +4 more
core +2 more sources
Variable termination sites of DNA polymerases encountering a DNA-protein cross-link. [PDF]
PLoS ONE, 2018 DNA-protein cross-links (DPCs) are important DNA lesions induced by endogenous crosslinking agents such as formaldehyde or acetaldehyde, as well as ionizing radiation, cancer chemotherapeutic drugs, and abortive action of some enzymes.
Anna V Yudkina +2 more
doaj +1 more source
Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA [PDF]
, 2009 Rad51 is a DNA recombinase functioning in the repair of DNA double-strand breaks and the generation of genetic diversity by homologous recombination (HR).
Antony, Edwin +5 more
core +2 more sources
Nanomaterials, 2013 Separation of short single- and double-stranded DNA typically requires gel electrophoresis followed by DNA extraction, which is a time consuming process.
Po-Jung Jimmy Huang, Juewen Liu
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Single-stranded binding proteins and helicase enhance the activity of prokaryotic argonautes in vitro. [PDF]
PLoS ONE, 2018 Prokaryotic argonautes are a unique class of nucleic acid-guided endonucleases putatively involved in cellular defense against foreign genetic elements.
Eric A Hunt +2 more
doaj +1 more source
Frontiers in Microbiology, 2012 Single-stranded DNA binding proteins play an essential role in DNA replication and repair. They use oligosaccharide-binding folds, a five-stranded ß-sheet coiled into a closed barrel, to bind to single-stranded DNA thereby protecting and stabilizing
Amy eStroud +2 more
doaj +1 more source
Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex
Nature Communications, 2022 Here the authors probe the cleavage and gate opening of single-stranded DNA by the human topoisomerase TRR using a unique single-molecule strategy to reveal structural plasticity in response to both double-stranded DNA and the helicase BLM.
Julia A. M. Bakx +8 more
doaj +1 more source