Results 11 to 20 of about 578,499 (184)

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Nature Communications, 2021
Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell ...
Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer   +5 more
doaj   +1 more source

Capture and analysis of double‐stranded DNA with the α‐hemolysin nanopore: Fundamentals and applications

Electrochemical Science Advances, 2022
The α‐hemolysin nanopore has attracted much attention as a tool for the single‐molecule analysis of DNA due to its potential as an ultra‐sensitive, specific, and label‐free sensing technique. The vast majority of DNA sensing research with the α‐hemolysin
Shekemi Denuga, Donal E. Whelan, Shane P. O'Neill, Robert P. Johnson   +3 more
doaj   +1 more source

Biochemical analysis of human Dna2 [PDF]

, 2006
Yeast Dna2 helicase/nuclease is essential for DNA replication and assists FEN1 nuclease in processing a subset of Okazaki fragments that have long single-stranded 5' flaps. It is also involved in the maintenance of telomeres.
Campbell, Judith L., Imamura, Osamu, Masuda-Sasa, Taro   +2 more
core   +4 more sources

Molecular Spiders in One Dimension [PDF]

, 2007
Molecular spiders are synthetic bio-molecular systems which have "legs" made of short single-stranded segments of DNA. Spiders move on a surface covered with single-stranded DNA segments complementary to legs.
Alberts B, Alexander S, Antal T Krapivsky P L, Antal T Krapivsky P L Mallick K, Chen N Y, Derrida B, Derrida B, Derrida B, Derrida B, Fedders P A, Howard J, Kirone Mallick, Kolomeisky A B, Liggett T M, Mobilia M Reichenbach T Hinsch H Franosch T Frey E, Olah M J Stefanovic D, P L Krapivsky, Schütz G M, Shaw L B, Spohn H, Tibor Antal, Van Kampen N G   +21 more
core   +5 more sources

Cooperativity-Dependent Folding of Single-Stranded DNA

Physical Review X, 2021
The folding of biological macromolecules is a fundamental process of which we lack a full comprehension. Mostly studied in proteins and RNA, single-stranded DNA (ssDNA) also folds, at physiological salt conditions, by forming nonspecific secondary ...
X. Viader-Godoy, C. R. Pulido, B. Ibarra, M. Manosas, F. Ritort   +4 more
doaj   +1 more source

DNA Renaturation at the Water-Phenol Interface [PDF]

, 2003
We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
121, 125, 23, 262, 27, 276, 28, 289, 35, 376, 38, 381, 395, 41, 52, 56, 7, 740, 77, 82, 90, 90, 98, 98, Alberts, Anderson, Anderson, Belhachemi, Berg, Berg, Bernal, Brahms, Braun, Campell, Carri, Carrington, Cech, Chan, Chaperon, Chomczynski, Chow, Christiansen, Craig, Davis, Deamer, DiMarzio, Duckett, Eigen, Eigen, Eisenberg, Escara, Felsenfeld, Fleming, Gennes, Gierer, Gilbert, Gold, Grassmann, Grosberg, Hagenmuller, Hammes, Hearst, Hegner, Helmer, Herschlag, Herskovits, Hill, Jaeger, Joanicot, Joyce, Joyce, Joyce, Katcher, Kauzmann, Kirby, Kirby, Kirby, Kohne, Kowalczykowski, Lahav, Lang, Laurent, Lennard-Jones, Leo, Lerman, Levine, Lohman, Ma, Maier, Maier, Mandell, Manning, Marmur, Marmur, Massie, Meijering, Meuthen, Miller, Morimatsu, Nadassi, Nandi, Neidle, Noller, Oparin, Pace, Pace, Paecht-Horowitz, Papafil, Pelta, Perutz, Piechowska, Piechowska, Pontius, Prigogine, Pusztai, Pörschke, Rhodes, Richter, Riggs, Robertson, Rothman, Saenger, Saito, Saxinger, Schaper, Schürmann, Sevag, Sikorav, Singer, Sinsheimer, Skinner, Smith, Smoluchowski, Studier, Studier, Szostak, Tabor, Tikhonenko, Timmermans, Tor, Tsang, Tsuchihashi, Ts’o, Ts’o, Vesnaver, Wagner, Wang, Ward, Weinstock, Westhof, Wetmur, Wetmur, Widom, Wieder, Winter, Woese, Wolfe, Zaks, Zaks, Zasloff, Zhulina, Ölçer   +161 more
core   +4 more sources

Hypermutation in single-stranded DNA

DNA Repair, 2020
Regions of genomic DNA can become single-stranded in the course of normal replication and transcription as well as during DNA repair. Abnormal repair and replication intermediates can contain large stretches of persistent single-stranded DNA, which is extremely vulnerable to DNA damaging agents and hypermutation.
Saini, Natalie, Gordenin, Dmitry A.
openaire   +2 more sources

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD [PDF]

, 2013
The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity were measured using bulk solution and a single-molecule imaging technique to investigate the ...
Arbore, Arthur, Atkinson, Bird, Brune, Byrd, Byrd, Chao, Cheng, Christopher P. Toseland, Corrie, Dillingham, Dillingham, Dillingham, Dillingham, Dillingham, Fili, Fili, Gorbalenya, Greenstein, Gregory I. Mashanov, Iordanescu, Justin E. Molloy, Kunzelmann, Leatherbarrow, Lee, Levin, Liisa T. Chisty, Lohman, Lohman, Manosas, Mark S. Dillingham, Martin R. Webb, Mashanov, Natalia Fili, Niedziela-Majka, Noirot, Sellers, Singleton, Slatter, Soultanas, Soultanas, Soultanas, Subramanya, Thomas, Thomas, Toseland, Veaute, Velankar, Webb, Yamaguchi, Yang, Yarranton, Yeeles, Zhang   +54 more
core   +1 more source

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]

, 2013
Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed, Allison, Beckerman, Bunz, Burnett, Carthew, Castanotto, Chen, Chendrimada, Dunn, Ford, Ford, Haigis, Haringsma, Hirao, Jiang, Jiang, Jiang, Jollès, Khan, Kim, Knight, Liu, Liu, Lynch, Parker, Peritz, Rao, Rivas, Réfrégiers, Shah, Siomi, Song, Vickers, Wang, Wang, Wang, Ye, Yoshizawa   +38 more
core   +6 more sources

Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA [PDF]

, 2016
We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy.
Corradini, Roberto, Gyssels, Ellen, Madder, Annemieke, Manicardi, Alex   +3 more
core   +2 more sources