Results 81 to 90 of about 90,099 (199)

Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase

mBio
Type II topoisomerase utilizes the energy from ATP hydrolysis to alter DNA topology during genome replication and transcription. The ATPase domain of this enzyme is required for ATP hydrolysis and plays a crucial role in coupling DNA binding and ATP ...
Wenhua Kuang, Yan Zhao, Jinyue Li, Zengqin Deng   +3 more
doaj   +1 more source

Topoisomerases in Human Leukemia

, 1994
Publisher Summary The chapter reviews the regulation of topoisomerases in lymphohematopoietic tissues, describes the clinical use of topo-directed agents in the treatment of leukemia, and suggests areas for future research on mechanisms of resistance to the agents in the clinical setting.
D, Peereboom, M, Charron, S H, Kaufmann
openaire   +2 more sources

Rôle de la GTPase RhoB dans la réponse aux dommages à l'ADN induits par la camptothécine [PDF]

, 2013
RhoB est une GTPase impliquée dans diverses fonctions intracellulaires comme l'organisation du cytosquelette. En plus de ses rôles bien établis, RhoB a récemment émergé comme un gène de réponse précoce aux dommages à l'ADN.
Mamouni, Kenza
core  

TOPOISOMERASE-I AND TOPOISOMERASE-II ACTIVITY IN HUMAN BREAST, CERVIX, LUNG AND COLON-CANCER

, 1994
The identification of human DNA topoisomerases as cellular targets for active anti-cancer drugs has stimulated further interest in topoisomerase function in tumour biology.
SYMONDS, RP, BROWN, R, OATES, M, MCLEOD, HL, DOUGLAS, F, KAYE, SB, KEITH, WN, PRAKASH, D, VANDERZEE, AGJ   +8 more
core   +1 more source

Mathematical models characterising the kinetics and dynamics of topotecan to account for drug resistance mechanisms [PDF]

This thesis describes the use of mathematical modelling in studying the kinetics and dynamics of the anti-cancer agent topotecan (TPT), a semi-synthetic derivative of the natural extract camptothecin (CPT), which has been found to act as an inhibitor ...
Atari, M. I. (Mohammed Isam)
core  

Topoisomerase 1

topoisomerase 1 role in transcription data for ...
Vega, M
core   +1 more source

Aclacinomycin A stabilizes topoisomerase I covalent complexes.

, 1997
International audienceAclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid tumors.
Nitiss, J, Pommier, Y, Pourquier, P.
core   +1 more source

Detection of DNA Gyrase Mutation and Multidrug Efflux Pumps Hyperactivity in Ciprofloxacin Resistant Clinical Isolates of Pseudomonas aeruginosa

Journal of Medical Microbiology and Infectious Diseases, 2013
Target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in Pseudomonas aeruginosa. We performed a genotypic characterization of three major Mex multidrug efflux pumps (MexAB-OprM, MexXY ...
Abolghasem Tohidpour, Shahin Najar Peerayeh, Sarah Najafi   +2 more
doaj  

Quinoline-Based Scaffolds in Anticancer Drug Discovery: Molecular Targets, Synthetic Strategies, and Biological Advances. [PDF]

ChemMedChem
Raza A, Wadhwa P, Sharma S.
europepmc   +1 more source

Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening. [PDF]

Biotechnol J
Yu T, Jang WD, Lee SY.
europepmc   +1 more source