TOP1 and TOP2 complementarily maintain DNA replication fork progression in vertebrates. [PDF]
J Biol ChemUmemura K +6 more
europepmc +1 more source
Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy
MedComm – Oncology, Volume 5, Issue 2, June 2026.Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley +1 more source
Enzyme-DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs. [PDF]
ACS Infect DisArmenia JF, Osheroff N.
europepmc +1 more source
Fabrication of Biocompatible PVA Nanofiber Composites With Antioxidant and Antibacterial Activities
Polymers for Advanced Technologies, Volume 37, Issue 6, June 2026.ABSTRACT This study aims to develop polyvinyl alcohol (PVA)‐based bioactive nanofiber composites incorporating quercetin, mesoporous silica nanoparticles (MSNs), and ciprofloxacin (CIP) for potential applications in biomedical and cosmetic fields.
Yara Farrah +6 more
wiley +1 more source
Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity. [PDF]
Front PharmacolEldehna WM +11 more
europepmc +1 more source
Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
In silico evaluation of garlic-derived organosulfur compounds as multi-target inhibitors of breast cancer biomarkers. [PDF]
PLoS OneSiame C, Ofori B, Paemka L, Danquah KO.
europepmc +1 more source
Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes
Protein Science, Volume 35, Issue 6, June 2026.Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin +2 more
wiley +1 more source
Coumarin-Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents. [PDF]
Chem Biol Drug DesMatar IK +6 more
europepmc +1 more source
Sequence and structural alignments reveal insights into ANKLE2 evolution and function
Protein Science, Volume 35, Issue 6, June 2026.Abstract ANKLE2 is an enigmatic protein with emerging roles in cell division, development, and virus replication. While ANKLE2 orthologs are present in all animals, its domain composition has evolved over time. ANKLE2's two namesake domains, the ankyrin repeat and LEM domains (named for LAP2, Emerin, and MAN1), have clear and defined roles; however ...
Adam T. Fishburn +8 more
wiley +1 more source