Results 101 to 110 of about 66,338 (163)

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Model to Predict Drug–Drug Interactions With the Antibody–Drug Conjugate Trastuzumab Deruxtecan

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.
ABSTRACT The topoisomerase I inhibitor payload (DXd) released from the human epidermal growth factor receptor 2‐targeted antibody–drug conjugate (ADC) trastuzumab deruxtecan (T‐DXd) is eliminated by hepatic uptake via OATP1B1/3, metabolism by CYP3A, biliary excretion via P‐glycoprotein and breast cancer resistance protein, and urinary excretion.
Akiko Watanabe, Katherine L. Gill, Kuan‐Fu Chen, Hannah M. Jones, Mailys De Sousa Mendes, Iain Gardner, Masakatsu Kotsuma   +6 more
wiley   +1 more source

The Roles of Topoisomerases in Transcriptional Regulation. [PDF]

Int J Mol Sci
Fenelon KD, Madabhushi R.
europepmc   +1 more source

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source

Microbial Primer: Bacterial DNA supercoiling. [PDF]

Microbiology (Reading)
Dorman CJ.
europepmc   +1 more source

Research Progress on Metal‐Organic Framework Materials in Corrosion‐Resistant and Antimicrobial Metal Functional Coatings

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Metal‐organic frameworks (MOFs) hold significant potential across numerous advanced disciplines due to their exceptional properties, including high specific surface area, tunable porosity, structural diversity, and customizable functionality. Increasing attention has been directed toward employing MOFs in coatings that offer both antimicrobial
Yanchun Zhao, Yunbo Lan, Qi Chang, Fei Zhou, Yongsheng Lin, Peter K. Liaw, Peiqing La, Faqi Zhan   +7 more
wiley   +1 more source

Repositioning of Fluoroquinolones: A New Approach in Antitumor Therapy. [PDF]

Biology (Basel)
da Silva JR, de Souza JB, de Oliveira LL, de Almeida Campos LA, Cavalcanti IMF.   +4 more
europepmc   +1 more source

Genome‐wide association studies reveal environment‐dependent genetic associations for plant architecture in regional soybean germplasm

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Regional soybean (Glycine max (L.) Merr.) breeding has produced germplasm adapted to different growing seasons, but the transferability of genetic associations associated with plant architecture across populations remains unclear. We performed genome‐wide association studies (GWASs) for plant height and main stem node number in 520 soybean ...
Pengshuo Shen, Qing Yang, Zheng Shi, Zhi Liu, Yan Feng, Sobhi F. Lamlom, Honglei Ren, Fulong Liu, Jiahao Ma, Yuechen Zhang, Long Yan   +10 more
wiley   +1 more source

Deruxtecan-based antibody-drug-conjugates induce senescence in HER2-positive breast cancer. [PDF]

Sci Rep
Vezzoli E, Pinos R, Galbiati S, Zambroni D, Dall'Ara C, Locatelli A, Colombo E, Galbardi B, Viganò L, Lavagnino Z, Scielzo C, De Palma C, Bianchini G, Tacchetti C, Daniele T.   +14 more
europepmc   +1 more source

Senescent Myoblasts Exhibit ROS‐Dependent Akt‐mTORC1 Dysregulation and Are Susceptible to Reductive Stress‐Induced Cell Death

Aging Cell, Volume 25, Issue 6, June 2026.
Senescent myoblasts exhibit dysregulated Akt/mTORC1 signalling. Antioxidants can alleviate this dysregulation, as well as other downstream senescent phenotypes. Moreover, prolonged antioxidant treatment can selectively induce cell death in senescent myoblasts, suggesting that these cells are more susceptible to reductive stress.
Vladimir Belhac, Alex Dillingham, Emilia Coward, Bradley Teal, Mark C. Turner, Stephanie D. Gagnon, Jiani Qian, Harry Wilford, Ella Warren, Natalie Moger, Bernadette Carroll, Owen G. Davies, Hannah F. Dugdale, Neil R. W. Martin   +13 more
wiley   +1 more source