Results 101 to 110 of about 90,099 (199)

Hydrogen-deuterium exchange points to inter-domain interactions in reverse gyrase that modulate conformational changes in positive DNA supercoiling. [PDF]

J Biol Chem
Mhaindarkar VP, Collin F, Koldewey P, Klostermeier D.   +3 more
europepmc   +1 more source

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

Quantum dot (QD)-based silicon as an efficient catalyst for the one-pot synthesis of polynuclear acridines: molecular docking investigation of putative anti-tubercular and anti-HIV drug candidates. [PDF]

RSC Adv
Tarek M, Said GE, Al-Omar MA, Almehizia AA, Naglah AM, Alshammari A, Ghabbour HA, Khatab TK.   +7 more
europepmc   +1 more source

PAF1c depletion confers chemoresistance to topoisomerase inhibitors. [PDF]

Cell Insight
Li D, Zhu C, Wang T, Chen Q, Chen Q.
europepmc   +1 more source

Genetic Background Modulates Zoliflodacin and Gepotidacin Cross-Resistance and Fitness in Neisseria gonorrhoeae. [PDF]

J Infect Dis
Mukherjee A, Blomqvist SOP, Helekal D, Das AA, Palace SG, Grad YH.   +5 more
europepmc   +1 more source

Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition. [PDF]

Mar Drugs
Seekins CA, Archuleta MR, Evans AE, Podgorski J, Carr JE, Kaleeswaran V, Nguyen KB, Flowers ME, Hulme C, Vanderah TW, Cárdenas P, Streicher JM, Lee NY, Cartmell C.   +13 more
europepmc   +1 more source

Antibody-Drug Conjugates Targeting HER2 and Trop-2: A New Force in Precision Treatment for Solid Tumors. [PDF]

Pharmaceuticals (Basel)
Jiang Z, Mei C, Lyu X, Liu Z, Li Z, Xing B, Liu Y, Li G, Wang H.   +8 more
europepmc   +1 more source

Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors. [PDF]

J Hematol Oncol
Lou J, Lyu Y.
europepmc   +1 more source

Novel Camptothecin-Based Lipid Conjugated with Steroids and Triterpene Acids: Enhanced Cellular Uptake and Topoismerase I Inhibition. [PDF]

Pharmaceutics
Chobanov NM, Vakhnin KO, Logunov SE, Fedorov AE, D'yakonov GV, Dzhemilev UM, Dzhemileva LU, D'yakonov VA.   +7 more
europepmc   +1 more source

Combination of PARPi and topoisomerase I inhibitors is highly effective in olaparib-resistant ovarian cancer. [PDF]

Exp Hematol Oncol
Chiappa M, Villa V, Sias F, Grasselli C, Sala L, Canesi S, Marabese M, Mason S, Dibitetto D, Fruscio R, Damia G.   +10 more
europepmc   +1 more source