Results 101 to 110 of about 146,499 (323)

Association between the c.*229C>T polymorphism of the topoisomerase IIb binding protein 1 (TopBP1) gene and breast cancer [PDF]

, 2012
Topoisomerase IIb binding protein 1 (TopBP1) is involved in cell survival, DNA replication, DNA damage repair and cell cycle checkpoint control. The biological function of TopBP1 and its close relation with BRCA1 prompted us to investigate whether ...
A Jemal, A Yokoyama, Agnieszka Szymczyk, Anna Krześlak, Beata Smolarz, BF Pachkowski, CW Elston, D Fanale, DP Bartel, E Forma, Ewa Brzeziańska, Ewa Forma, G Corrao, G Papagregoriou, Grażyna Chwatko, Hanna Romanowicz-Makowska, ID Fleming, J Shen, JNM Glover, JS Morris, JS Morris, K Liu, K Metsola, LE Mechanic, M Sokka, Magdalena Bryś, MC Rodriguez, P Reynolds, Paweł Jóźwiak, PJ Brooks, RE Shore, S Chatterjee, S Peng, SM Karppinen, SS Coughlin, Waldemar Różański, X Liu, Y Jeon, Y Xu   +38 more
core   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Divergent RNA transcription:A role in promoter unwinding? [PDF]

, 2013
New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction.
Corless, Samuel, Gilbert, Nick, Naughton, Catherine   +2 more
core   +1 more source

Two type I topoisomerases maintain DNA topology in human mitochondria

, 2022
Katja E. Menger, James Chapman, Héctor Díaz-Maldonado, Mushtaq M. Khazeem, Dasha Deen, Direnis Erdinc, John Casement, Valeria Di Leo, Angela Pyle, Alejandro Rodríguez‐Luis, Ian G. Cowell, Maria Falkenberg, Caroline A. Austin, Thomas J. Nicholls   +13 more
openalex   +1 more source

Gastric signet‐ring cell carcinoma in a child: A clinical case study

JPGN Reports, EarlyView.
Abstract Gastric signet‐ring cell carcinoma (SRCC) is a rare form of gastric cancer characterized by mucus‐rich tumor cells forming a distinctive ring‐like appearance and is exceedingly rare in children, accounting for less than 1% of all childhood malignancies.
Jiaxian Wang, Yang Yang, Jiangnan Wei, Jiayin Chen, Kezhou Yang, Chao Hui He, Ning Liu   +6 more
wiley   +1 more source

Cryptolepine, a Plant Alkaloid, Inhibits the Growth of Non-Melanoma Skin Cancer Cells through Inhibition of Topoisomerase and Induction of DNA Damage

Molecules, 2016
Topoisomerases have been shown to have roles in cancer progression. Here, we have examined the effect of cryptolepine, a plant alkaloid, on the growth of human non-melanoma skin cancer cells (NMSCC) and underlying mechanism of action.
Harish C. Pal, Santosh K. Katiyar
doaj   +1 more source

Senescent human diploid fibroblasts are able to support DNA synthesis and to express markers associated with proliferation [PDF]

, 1990
The characteristic limited reproductive life-span of normal human fibroblasts in culture is due to a steadily decreasing fraction of cells able to proliferate in the standard rich growth media.
Kill, IR, Shall, S
core  

Double-strand break repair and homologous recombination in Schizosaccharomyces pombe [PDF]

, 2006
In recent years our understanding of double strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased ...
Ahmad, Ahmad, Ahn, Ahnesorg, Akamatsu, Assenmacher, Baumann, Boddy, Boddy, Bonatto, Bransteitter, Buck, Callebaut, Caspari, Catlett, Cervantes, Chahwan, Cheok, Connelly, Cooper, Doe, Doe, Doe, Doe, Dudasova, Farah, Farah, Ferreira, Ferreira, Fukushima, Gaillard, Goedecke, Goodwin, Grishchuk, Haber, Hartsuiker, Hefferin, Jang, Jung, Khasanov, Khasanov, Kibe, Kim, Kim, Krogh, Lambert, Laursen, Macris, Maftahi, Maftahi, Manolis, Marchetti, Martin, McGlynn, Moore, Morishita, Muris, Muris, Muris, Murray, Nakada, Nakamura, Oakley, Ono, Osman, Osman, Osman, Ostermann, Paques, Parker, Prudden, Sauvageau, Schmidt, Segurado, Shinohara, Smith, Steiner, Stewart, Sung, Suto, Szankasi, Szostak, Tarsounas, Tavassoli, Thacker, Tomita, Tomita, Tsutsui, Tsutsui, Ueno, van den Bosch, van den Bosch, Virgin, Virgin, Wang, Weterings, Whitby, Whitby, Wilson, Win, Win, You, Young   +102 more
core   +2 more sources

Associations Between GLP‐1 Receptor Agonists and Alopecia: A Multi‐Centre Retrospective Analysis and Public Interest Trends

JEADV Clinical Practice, EarlyView.
ABSTRACT Background There is a growing body of literature suggesting that GLP‐1 receptor agonists (GLP‐1RAs) may be associated with hair loss; however, primary literature is sparse. Additionally, it is not well‐established which types of hair loss may be associated with GLP‐1RA use. Objectives This study aims to assess associations between GLP‐1RAs and
Lauren M. Ching, Christopher A. Guirguis, Joe K. Tung   +2 more
wiley   +1 more source

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives [PDF]

, 2018
Jessica Marinello, Maria Delcuratolo, Giovanni Capranico   +2 more
openalex   +1 more source