Results 121 to 130 of about 146,499 (323)

Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome [PDF]

, 1990
Min‐Liang Wong, M T Hsu
openalex   +1 more source

Polyhedral Oligomeric Silsesquioxane Based Material for Tumor Heterogeneity MR Visualization and Precise Treatment

SusMat, EarlyView.
ABSTRACT Malignant tumors whose mortality rates up to 97% possess high heterogeneity that leads to rapid growth, strong invasive capability, and low drug sensitivity. Quantitative magnetic resonance imaging enables direct visualization of tumors. However, gadolinium‐based contrast agents used in clinical practice have significant drawbacks of short ...
Xiaochuan Geng, Zhiguo Zhuang, Jiahui Zhang, Xinxin Zhao, Haiying Lyu, Zi Fu, Xi Liu, Ting Qian, Zhihui Li, Tongtong Chen, Qing Zhang, Yan Zhou, Yong Lu, Gang Wei   +13 more
wiley   +1 more source

The role of NF-Y in the transcriptional regulation of human topoisomerase II¯ : a thesis presented to Massey University in partial fulfilment of the requirement for the degree of Master of Science in Biochemistry [PDF]

, 2001
DNA topoisomerases are ubiquitous enzymes that catalyse reactions that alter the topological state of DNA during the various processes of DNA metabolism including transcription, recombination, replication and chromosome segregation. Human cells exhibit a
Hintz, Patricia Ann
core  

Cloning of the genetopA encoding for DNA topoisomerase 1 and the physical mapping of thecysB–topA–trpAregion ofEscherichia colt [PDF]

, 1983
James C. Wang, Kathleen Becherer
openalex   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, EarlyView.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Rapid, DNA-induced interface swapping by DNA gyrase

eLife
DNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the active complex.
Thomas RM Germe, Natassja G Bush, Victoria M Baskerville, Dominik Saman, Justin LP Benesch, Anthony Maxwell   +5 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase

mBio
Type II topoisomerase utilizes the energy from ATP hydrolysis to alter DNA topology during genome replication and transcription. The ATPase domain of this enzyme is required for ATP hydrolysis and plays a crucial role in coupling DNA binding and ATP ...
Wenhua Kuang, Yan Zhao, Jinyue Li, Zengqin Deng   +3 more
doaj   +1 more source

Topoisomerases

, 1998
Capítulo en: Ram S. Verma (ed.). Advances in Genome Biology, vol. 5B. [S.l.]: JAI Press, 1998, p.463-486. ISBN 0-7623-0079-5. ISBN 978-0-7623-0079-2 This chapter describes topoisomerases. Much progress has been made in structural and functional studies on DNA topoisomerases.
openaire   +2 more sources