TORCphysics: a physical model of DNA-topology-controlled gene expression. [PDF]
Nucleic Acids ResVelasco-Berrelleza V +7 more
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A high-throughput fluorescent DNA cleavage assay for discovering bacterial DNA gyrase poisons. [PDF]
Nucleic Acids ResDias M +9 more
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Design, synthesis, and antibacterial assessment of a new series of ciprofloxacin-based compounds as possible dual DNA gyrase/topoisomerase IV inhibitors. [PDF]
Sci RepAl-Wahaibi LH +4 more
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Modeling rotational fluoroquinolone therapy as a novel treatment for ophthalmic MRSA infections. [PDF]
Sci RepStorper A, Miller D, Huo X.
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A dual functional inhibitory molecule to combat GyrA-ParC and associated mutants in fluoroquinolone-resistant <i>Shigella flexneri</i> causing shigellosis: an ML guided and quantum simulation-based <i>in silico</i> approach. [PDF]
Front BioinformGhosh S, Ramaiah S.
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Trial watch: antibody-drug conjugates in cancer therapy. [PDF]
OncoimmunologyDoffe F +6 more
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Structure-Based Drug Design Targeting Topoisomerase II Alpha: Discovery of Potential Antitumor Xanthone Derivatives. [PDF]
MoleculesLe TTH +7 more
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Novel <i>N</i>-4-(5-Amino-7-substituted-triazolotriazinepiperazin-1-yl) Norfloxacin Analogues Exhibit Potent and Selective Anticancer Activity via Topoisomerase Inhibition, Cell-Cycle Arrest, and Apoptosis in A 431 Skin Carcinoma Cells. [PDF]
Pharmaceuticals (Basel)El-Saghier AM +4 more
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Current Protocols in Pharmacology, 2012 AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and pass double‐stranded DNA. DNA topoisomerases are important targets
Aman Seth
exaly +3 more sources