Two‐Phase Electrosynthesis of Dihydroxycoumestans: Discovery of a New Scaffold for Topoisomerase I Poison [PDF]
Yue‐Xi Chen +9 more
openalex +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Phytochemical-Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles. [PDF]
Phytother ResLung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Islam MR +14 more
europepmc +2 more sources
International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I [PDF]
, 2018 Luís Eduardo Coelho Andrade +10 more
openalex +1 more source
Accessing New Phenanthroline–Oxazine Scaffolds as Copper‐Dependent DNA Damaging Probes
ChemBioChem, Volume 27, Issue 8, 28 April 2026.New phenanthroline–oxazine ligands derived from natural amino acids are synthesized through an optimized, predictive strategy. When coordinated to copper, these scaffolds display tunable DNA binding, groove selectivity, and oxidative cleavage activity, revealing clear structure activity relationships and expanding the toolbox of copper‐dependent ...
Rebecca Lynn +10 more
wiley +1 more source
Anthraquinones from Neonauclea calycina and Their Inhibitory Activity against DNA Topoisomerase II.
, 1998 Hideki Tosa +9 more
openalex +2 more sources
MOLECULAR DOCKING STUDIES ON SOME BENZAMIDE DERIVATIVES AS TOPOISOMERASE INHIBITORS
, 2020 Serap Yilmaz +2 more
openalex +2 more sources
A case of juvenile localized scleroderma with anti-topoisomerase I antibody [PDF]
, 2019 Kyoko Shimizu +3 more
openalex +1 more source
ChemPhysChem, Volume 27, Issue 8, 28 April 2026.The solvation preference of irinotecan is governed by a competition between cavity formation and electrostatic stabilization. Computations reveal that the high cost of breaking water's hydrogen bond network outweighs its electrostatic benefits. In contrast, polar aprotic solvents (e.g., pyridine) offer an optimal thermodynamic balance, providing strong
Martin M. Bitabo +4 more
wiley +1 more source