Results 151 to 160 of about 90,099 (199)

Topoisomerases

2018
This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon, Vincent Croquette, Jean-François Allemand, Xavier Michalet, Terence Strick   +4 more
openaire   +1 more source

DNA topoisomerases and topoisomerase inhibitors.

Pathologie-biologie, 1995
DNA topoisomerases are ubiquitous nuclear enzymes, essential for several steps of DNA metabolism. They have recently been shown to be specific targets of a number of anticancer agents. In this review are discussed the most recent discoveries in the physiology and the molecular biology of DNA topoisomerases, and the mechanism of interaction with drugs ...
openaire   +1 more source

Inhibition of topoisomerases by fredericamycin A

Cancer Chemotherapy and Pharmacology, 1989
Fredericamycin is an antibiotic product of Streptomyces griseus that exhibits modest antitumor activity in vivo and in vitro. Because of its unique structure and the absence of a clearly defined mechanism of action, we examined the effects of this compound on L1210 cells in culture as well as on several enzymes that bind to DNA. Fredericamycin exhibits
M D, Latham, C K, King, P, Gorycki, T L, Macdonald, W E, Ross   +4 more
openaire   +2 more sources

Structure of DNA topoisomerases

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase ...
openaire   +2 more sources

DNA topoisomerases

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
openaire   +2 more sources

DNA topoisomerases

Current Opinion in Cell Biology, 1989
openaire   +2 more sources

Acridine derivatives as inhibitors/poisons of topoisomerase II

Journal of Applied Toxicology, 2022
Maria Kožurková
exaly  

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2? construct allows the study of topoisomerase II? inhibitors in yeast.

Cancer Chemotherapy and Pharmacology, 1997
Caroline Austin, Larry Mark Fisher, L Mark Fisher   +2 more
exaly  

DNA topoisomerases

Cell, 1980
openaire   +2 more sources

Dual topoisomerase I/II poisons as anticancer drugs

Expert Opinion on Investigational Drugs, 1997
William Denny
exaly