Results 161 to 170 of about 146,499 (323)

Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase.

, 1984
Kenneth N. Kreuzer, Bruce Alberts
openalex   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Alteration of Escherichia coli Topoisomerase IV Conformation upon Enzyme Binding to Positively Supercoiled DNA

, 2006
Nancy J. Crisona, Nicholas R. Cozzarelli
openalex   +1 more source

Pulmonary Function Decline in Very Early Diagnosis of Systemic Sclerosis: A Retrospective Longitudinal Single‐Center Study

ACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Objective The very early diagnosis of systemic sclerosis (SSc; VEDOSS) criteria aim to identify patients at risk of evolving into SSc. The predictive value of diffusing capacity of the lungs for carbon monoxide (DLco) and forced vital capacity (FVC) remains poorly characterized. This study aimed to evaluate whether baseline pulmonary function test (PFT)
Eugenio Capparelli, Greta Pellegrino, Eleonora Zaccara, Giorgio Bonardi, Elisabetta Ricchiuti, Daniele Colombo, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +8 more
wiley   +1 more source

Detection of DNA Gyrase Mutation and Multidrug Efflux Pumps Hyperactivity in Ciprofloxacin Resistant Clinical Isolates of Pseudomonas aeruginosa

Journal of Medical Microbiology and Infectious Diseases, 2013
Target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in Pseudomonas aeruginosa. We performed a genotypic characterization of three major Mex multidrug efflux pumps (MexAB-OprM, MexXY ...
Abolghasem Tohidpour, Shahin Najar Peerayeh, Sarah Najafi   +2 more
doaj  

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, Volume 15, Issue 15, 17 April 2026.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Evaluation of Two Models for Human Topoisomerase I Interaction with dsDNA and Camptothecin Derivatives

, 2011
Gary S. Laco
openalex   +2 more sources

The large subunit of Leishmania topoisomerase I functions as the ‘molecular steer’ in type IB topoisomerase [PDF]

, 2007
Somdeb BoseDasgupta, Agneyo Ganguly, Benu Brata Das, Amit Roy, Neeta V. M. Khalkho, Hemanta K. Majumder   +5 more
openalex   +1 more source

Architecture of an All‐In‐One Microfluidic Platform for Accelerated Cancer Seeding, Enhanced Spheroid Formation, and Dynamic Drug Screening Trials

Advanced Materials Technologies, Volume 11, Issue 7, 6 April 2026.
An all‐in‐one microfluidic platform consists of two‐layered PDMS channels integrated with a hydrogel microwell array. This platform enables flow‐driven tumor cell capture, enhanced spheroid formation within the microwells, and advective drug testing. ABSTRACT Effective cancer drug screening requires platforms that replicate the physiological complexity
Omar M. Rahman, Shengxi Lan, Dae Kun Hwang   +2 more
wiley   +1 more source

Topoisomerase inhibitors in cervical cancer: mechanistic insights and therapeutic strategies. [PDF]

Mol Med
Reddy Y, Pai P, Das I, Nayak S, D'Souza NV, Shetty MG, Sundara BK.   +6 more
europepmc   +1 more source