Results 161 to 170 of about 68,974 (263)

A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman, Joydeep Chatterjee, Gaurav Joshi, Raj Kumar, Muhammad Wahajuddin   +4 more
wiley   +1 more source

Synthesis, characterization, and anticancer potency of sulfadiazine salicylaldehyde-based Schiff bases. [PDF]

Sci Rep
Nasr E, Moustafa AH, El-Sayed ASA, Ali M.   +3 more
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Enzyme-DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs. [PDF]

ACS Infect Dis
Armenia JF, Osheroff N.
europepmc   +1 more source

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

ChemistryOpen, Volume 15, Issue 9, September 2026.
Three benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Gulay Dilek, Senem Akkoc
wiley   +1 more source

Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity. [PDF]

Front Pharmacol
Eldehna WM, Tawfik HO, Veselá D, Peřina M, Negmeldin AT, Elsayed ZM, Majrashi TA, Vojáčková V, Elbadawi MM, Shaldam MA, Kryštof V, Abdel-Aziz HA.   +11 more
europepmc   +1 more source

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang, Xing Wu, Maria Moreno, Joonseok Oh, Stephen L. Dellaporta, Jason M. Crawford, Farren J. Isaacs   +6 more
wiley   +1 more source

Coumarin-Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents. [PDF]

Chem Biol Drug Des
Matar IK, Zaki MEA, Muhammad ZA, Awwad DA, Al-Hussain SA, Matta CF, Kassab RM.   +6 more
europepmc   +1 more source

Antibacterial Efficacy of 6‐Gingerol Alone and in Combination With Enrofloxacin Against Multidrug‐Resistant Staphylococcus aureus Isolated From Goats

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Integrated mastitis screening effectively identified MRSA‐associated Staphylococcus aureus in goats, with the Surf Field Mastitis Test proving a reliable rapid diagnostic tool. Combination therapy of enrofloxacin and 6‐gingerol showed superior antibacterial activity, highlighting 6‐gingerol as a promising adjunct to combat antimicrobial‐resistant ...
Maria Khan, Arshad Zahoor, Shabana Naz, Caterina Losacco, Sohail Ahmad, Ibrahim A. Alhidary, Luciana Rossi, Rifat Ullah Khan, Huda A. Alqahtani   +8 more
wiley   +1 more source

In silico evaluation of garlic-derived organosulfur compounds as multi-target inhibitors of breast cancer biomarkers. [PDF]

PLoS One
Siame C, Ofori B, Paemka L, Danquah KO.
europepmc   +1 more source