Results 181 to 190 of about 146,499 (323)

DNA Topoisomerase Top3β Is Impacted by Early Life Stress in the Developing Female and Male Rat Brain

, 2022
Amelia Cuarenta, Stacey L. Kigar, Ashley P. Keese, Sarah Anne J. Guagliardo, Liza Chang, Vaishali P. Bakshi, Anthony P. Auger   +6 more
openalex   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Isoquercitrin Alleviates 5‐Fluorouracil‐Induced Intestinal Mucositis in Mice by Modulating Inflammation and Oxidative Stress

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the role of isoquercitrin (ISO) in 5‐fluorouracil‐induced intestinal mucositis. The animals (6 animals/group) were divided into: vehicle (2% DMSO), 5‐fluorouracil (5‐FU) and groups receiving ISO (10, 50, or 100 mg/kg).
Lázaro de Sousa Fideles, Matheus da Silva Campelo, João Francisco Câmara Neto, Conceição da Silva Martins, João Erivan Façanha Barreto, Ícaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Maria Elenir Nobre Pinho Ribeiro   +8 more
wiley   +1 more source

Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity. [PDF]

Front Pharmacol
Eldehna WM, Tawfik HO, Veselá D, Peřina M, Negmeldin AT, Elsayed ZM, Majrashi TA, Vojáčková V, Elbadawi MM, Shaldam MA, Kryštof V, Abdel-Aziz HA.   +11 more
europepmc   +1 more source

Topoisomerase [PDF]

, 2020
openaire   +1 more source

Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts of maize [PDF]

, 1983
Siedlecki, Janusz, Weissbach, Arthur, Zimmermann, Wolfgang   +2 more
core  

Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology [PDF]

, 2019
Syed Moiz Ahmed, Peter Dröge
openalex   +1 more source

Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Pharmacovigilance has revealed an alarming correlation between certain medications and a higher risk of cancer. In this narrative review, included research from 2020 to 2025, along with a few seminal older studies, so that it provides a clear picture of which drugs actually set off cancer and mechanisms involved at the molecular ...
Desta Seyoum Tadesse, Kalkidan Tekletsadik, Berhan Begashaw, Awgichew Shewasinad Yehualashet, Awol Mekonnen Ali, Kassahun Dires Ayenew   +5 more
wiley   +1 more source

TOP1 and TOP2 complementarily maintain DNA replication fork progression in vertebrates. [PDF]

J Biol Chem
Umemura K, Ooka M, Sojo M, Seki M, Xia M, Hirota K, Abe T.   +6 more
europepmc   +1 more source

Studies of the topoisomerase and cofactor requirements for nucleosome reconstitution in a yeast chromatin assembly system

, 1997
Wendy I. Garinther
openalex   +1 more source