Results 201 to 210 of about 146,499 (323)

Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer [PDF]

, 2017
Chen, Ina, et al,
core   +2 more sources

Supplementary Figure 5 from RAP80 Acts Independently of BRCA1 in Repair of Topoisomerase II Poison-Induced DNA Damage

, 2023
Junko Iijima, Zhihong Zeng, Shunichi Takeda, Yoshihito Taniguchi   +3 more
openalex   +1 more source

A LAT1‐Compatible, Leadlike Tyrosine‐Naphthoquinone Conjugate With Anticancer Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT A L‐type amino acid transporter 1 (LAT1)‐compatible, anticancer‐active tyrosine‐naphthoquinone (NQ) conjugate was successfully developed. The conjugate was designed to exploit LAT1 overexpression in cancers with the goal of achieving selective cytotoxicity for cancerous over noncancerous cells.
Austin Seymour, Christian Peterson, Raymond Osafo, Abdullahi A. Ashimi, Dylan Williams, Laura Echezabal, Chelsea Carrier, Alysa Clarke, Clifford W. Padgett, Mark Vincent C. dela Cerna, Zheni Utic, Divine Wanduku, Nathaniel Shank, Karelle S. Aiken, Jannet Kocerha   +14 more
wiley   +1 more source

The Roles of Topoisomerases in Transcriptional Regulation. [PDF]

Int J Mol Sci
Fenelon KD, Madabhushi R.
europepmc   +1 more source

Supplementary Figure 4 from RAP80 Acts Independently of BRCA1 in Repair of Topoisomerase II Poison-Induced DNA Damage

, 2023
Junko Iijima, Zhihong Zeng, Shunichi Takeda, Yoshihito Taniguchi   +3 more
openalex   +1 more source

Phylogenetic Analyses of True Ladybirds (Coleoptera: Coccinellidae: Coccinellini) Reveal Directionality in Diet Evolution and Support a Boreotropical Origin of the Tribe

Ecology and Evolution, Volume 16, Issue 4, April 2026.
A newly generated large‐scale molecular phylogeny of true ladybirds (Coccinellini) clarifies their evolutionary relationships and supports a boreotropical origin in the Paleocene, with multiple independent southward dispersals. Ancestral diet reconstructions suggest an initial specialization on aphids, followed by expansions in host range and ...
Romain Nattier, Noémie M.‐C. Hévin, Pascaline Chifflet‐Belle, Jiajia Dong, Hermes E. Escalona, Julien M. Haran, Jean‐Claude Streito, Wioletta Tomaszewska, Adam Slipiński, Andreas Zwick, Gael J. Kergoat   +10 more
wiley   +1 more source

Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors

, 2012
William Guerrant, Vishal Patil, Joshua C. Canzoneri, Adegboyega K. Oyelere   +3 more
openalex   +1 more source

Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors [PDF]

, 2019
Roxana M. Rodríguez Stewart, Jameson Berry, Angela K. Berger, Sung Bo Yoon, Jaime A. Guberman, Nirav Patel, Gregory K. Tharp, Steven E. Bosinger, Bernardo A. Mainou   +8 more
openalex   +1 more source

Data from The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates the Effects of Topoisomerase I Poisons by Suppressing Rad51 Expression in a p53-Dependent Manner

, 2023
Grazia Ambrosini, Sharon L. Seelman, Li‐Xuan Qin, Gary K. Schwartz   +3 more
openalex   +1 more source

Protective Effect of Silymarin Against Paclitaxel‐Induced Cardiotoxicity

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Paclitaxel, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis leading to cardiotoxicity. In this study, silymarin supplementation significantly reduced oxidative stress markers, downregulated inflammatory cytokines (IL‐1β, TNF‐α, NF‐κB), and restored the balance between pro‐ and anti‐apoptotic proteins in rat heart ...
Tuğçe Tutar, Seda Yakut, Adem Kara, Aykut Ulucan, Cüneyt Çağlayan   +4 more
wiley   +1 more source