Results 71 to 80 of about 90,099 (199)
Molecules, 2012 Benzo[<em>c</em>]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity.
Thi-Ngoc-Phuong Huynh +3 more
doaj +1 more source
Discovery of New DNA Topoisomerase II Inhibitors using Structure Based Virtual Screening Method
Journal of the Turkish Chemical Society, Section A: Chemistry, 2019 DNA topoisomerases are proved therapeutic targets of anticancer and antibacterial drugs. Structures of topoisomerase–DNA and inhibitor ternary complexes have revealed the exact binding sites and mechanisms of topoisomerase poisons. There are two isoforms
Tugba Ertan-Bolelli, Kayhan Bolelli
doaj +1 more source
Thaspine is a topoisomerase inhibitor.
, 2013 (A) Connectivity Map (CMAP) results after treatment with thaspine. The bar view is constructed from 6100 horizontal lines, each representing a single treatment and ordered according to their corresponding enrichment to the query signatures generated ...
Maria Hägg Olofsson (145911) +5 more
core +1 more source
A functional type I topoisomerase from [PDF]
, 2009 Background: Pseudomonas aeruginosa encodes a putative topoisomerase with sequence similarity to the eukaryotic type IB topoisomerase from Vaccinia virus.
Jain, Teesta +2 more
core +1 more source
The human topoisomerase I damage response plays a role in apoptosis
, 2004 Previous studies have shown that human topoisomerase I cleavage complexes form as a response to various DNA damages in vivo, the so called human topoisomerase I "damage response".
Søe, Kent +4 more
core +1 more source
Caracterização das DNA topoisomerases II de Trypanosoma rangeli [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010DNA topoisomerases são enzimas que participam de diversos processos celulares tais como: replicação ...
Stoco, Patrícia Hermes
core
Pharmacological ResearchMany drugs have been discontinued during phase II/III breast cancer clinical trials due to lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data.
Xiaodan Zhang +9 more
doaj +1 more source
Exploring the Role of Topoisomerase II Beta in Macrophage Maturation and Pro-inflammatory Cytokine Production [PDF]
Although it is known that DNA topo IIβis required for the regulation of transcription during neural development and differentiation, it is not clear whether the enzyme is required during differentiation of human monocytes into macrophages and/or the ...
Roythorne, Ashleigh
core
Association of DNA topoisomerase I and RNA polymerase I: A possible role for topoisomerase I in ribosomal gene transcription [PDF]
, 1988 RNA polymerase I preparations purified from a rat hepatoma contained DNA topoisomerase activity. The DNA topoisomerase associated with the polymerase had an Mr of 110000, required Mg2+ but not ATP, and was recognized by anti-topoisomerase I antibodies ...
Szopa, Jan +5 more
core +2 more sources
Rapid, DNA-induced interface swapping by DNA gyrase
eLifeDNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the active complex.
Thomas RM Germe +5 more
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