Results 71 to 80 of about 66,338 (163)

Structure-Based Drug Design Targeting Topoisomerase II Alpha: Discovery of Potential Antitumor Xanthone Derivatives. [PDF]

Molecules
Le TTH, Nguyen TNH, Pham MQ, Tran TTT, Dinh TT, Tran THV, Tran VL, Pham QL.   +7 more
europepmc   +1 more source

Modeling rotational fluoroquinolone therapy as a novel treatment for ophthalmic MRSA infections. [PDF]

Sci Rep
Storper A, Miller D, Huo X.
europepmc   +1 more source

TORCphysics: a physical model of DNA-topology-controlled gene expression. [PDF]

Nucleic Acids Res
Velasco-Berrelleza V, Rainford PF, Mogre A, Benham CJ, Dorman CJ, Kröger C, Stepney S, Harris SA.   +7 more
europepmc   +1 more source

Novel <i>N</i>-4-(5-Amino-7-substituted-triazolotriazinepiperazin-1-yl) Norfloxacin Analogues Exhibit Potent and Selective Anticancer Activity via Topoisomerase Inhibition, Cell-Cycle Arrest, and Apoptosis in A 431 Skin Carcinoma Cells. [PDF]

Pharmaceuticals (Basel)
El-Saghier AM, Hamed AM, Abosella L, Bräse S, Aziz HA.   +4 more
europepmc   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Sequencing antibody-drug conjugates in metastatic cancer (Review). [PDF]

Med Int (Lond)
Abdalla BA.
europepmc   +1 more source

Synergistic Effects of IMP‐1700, Ciprofloxacin, and X‐Ray Radiation in Bacteria and Mammalian Cell Lines: Implications for Use in Antimicrobial‐Resistant Bacteria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
IMP‐1700 enhances the cytotoxic effect on bacteria in combination with either ciprofloxacin (CPX) or X‐ray. In noncancerous and tumor cells, combination treatments markedly reduce viability with radiosensitizing effects. Further studies are needed to clarify the mechanism underlying IMP‐1700s effects on mammalian cells. Created in BioRender. Kjaer, A. (
Ida Vang Andersen, Ane Beth Sloth, Emilie Caroline Skuladottir Bøgestad, Christian Bernard Matthijs Poulie, Anne Skovsbo Clausen, Umberto Maria Battisti, Matthias M. Herth, Andreas Kjaer   +7 more
wiley   +1 more source

Antibody-Drug Conjugates: Pharmacotherapeutic Properties and Future Perspectives. [PDF]

Pharmaceutics
Augusto A, Cristiano MLS, Conceição J.
europepmc   +1 more source

Short‐Term, Cycle‐Synchronized Adjunctive Therapy With Crocus Total Glucosides Tablets for Cardiac Protection Against Cancer Therapy‐Related Cardiac Dysfunction in Breast Cancer Patients: A Randomized, Double‐Blind, Placebo‐Controlled Trial

MedComm, Volume 7, Issue 6, June 2026.
Cycle‐synchronized CTGT therapy attenuates LVGLS decline and reduces CTRCD in breast cancer patients. This randomized, double‐blind, placebo‐controlled trial assessed whether cycle‐synchronized CTGT prevent CTRCD in 120 breast cancer patients receiving chemotherapy.
Xiaoling Liu, Mengmeng Li, Wenwen Song, Yu Zhang, Wuyun Bao, Chaoyu Liu, Yuan Zhang, Quande Liu, Cheng Zhang, Yun Zhang, Li Li, Mei Zhang   +11 more
wiley   +1 more source

Topoisomerase II binding protein 1-interacting checkpoint and replication regulator promotes lung adenocarcinoma proliferation by regulating myelocytomatosis oncogene signaling pathway. [PDF]

Cytojournal
Zhao Y, Feng Y, Guo M, Li L.
europepmc   +1 more source