Results 41 to 50 of about 90,099 (199)

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Química Nova, 2012
Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA.
Amanda de Melo Bezerra, Antônio Cláudio da Silva Lins, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, José Maria Barbosa-Filho, Celso Amorim Camara, Tania Maria Sarmento Silva, Vanessa da Silva Luna, Creusioni Figueredo dos Santos   +8 more
doaj   +1 more source

Type IA Topoisomerases as Targets for Infectious Disease Treatments

Microorganisms, 2021
Infectious diseases are one of the main causes of death all over the world, with antimicrobial resistance presenting a great challenge. New antibiotics need to be developed to provide therapeutic treatment options, requiring novel drug targets to be ...
Ahmed Seddek, Thirunavukkarasu Annamalai, Yuk-Ching Tse-Dinh   +2 more
doaj   +1 more source

The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90

Molecules, 2021
Xestoquinone is a polycyclic quinone-type metabolite with a reported antitumor effect. We tested the cytotoxic activity of xestoquinone on a series of hematological cancer cell lines.
Kuan-Chih Wang, Mei-Chin Lu, Kai-Cheng Hsu, Mohamed El-Shazly, Shou-Ping Shih, Ssu-Ting Lien, Fu-Wen Kuo, Shyh-Chyun Yang, Chun-Lin Chen, Yu-Chen S. H. Yang   +9 more
doaj   +1 more source

Refined Method for Droplet Microfluidics-Enabled Detection of Plasmodium falciparum Encoded Topoisomerase I in Blood from Malaria Patients

Micromachines, 2015
Rapid and reliable diagnosis is essential in the fight against malaria, which remains one of the most deadly infectious diseases in the world. In the present study we take advantage of a droplet microfluidics platform combined with a novel and user ...
Marianne Smedegaard Hede, Patricia Nkem Okorie, Signe Kirk Fruekilde, Søren Fjelstrup, Jonas Thomsen, Oskar Franch, Cinzia Tesauro, Magnus Tobias Bugge, Mette Christiansen, Stéphane Picot, Felix Lötsch, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Ayôla A. Adegnika, Finn Skou Pedersen, Yi-Ping Ho, Eskild Petersen, Magnus Stougaard, Michael Ramharter, Birgitta Ruth Knudsen   +19 more
doaj   +1 more source

How do neurons live long and healthy? The mechanism of neuronal genome integrity

Frontiers in Neuroscience
Genome DNA of neurons in the brain is unstable, and mutations caused by inaccurate repair can lead to neurodevelopmental and neurodegenerative disorders. Damage to the neuronal genome is induced both exogenously and endogenously. Rapid cell proliferation
Dai Ihara, Nur Rasyiqin Rasli, Yu Katsuyama   +2 more
doaj   +1 more source

Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12

Neurobiology of Disease, 2002
Mutations in presenilin-1 (PS1) can cause early onset familial Alzheimer's disease (AD). Studies of cultured cells and mice expressing mutant PS1 suggest that PS1 mutations may promote neuronal dysfunction and degeneration by altering cellular calcium ...
Sic L. Chan, Carsten Culmsee, Norman Haughey, Wolfram Klapper, Mark P. Mattson   +4 more
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

Marine Drugs, 2015
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively.
Shou-Ping Shih, Man-Gang Lee, Mohamed El-Shazly, Yung-Shun Juan, Zhi-Hong Wen, Ying-Chi Du, Jui-Hsin Su, Ping-Jyun Sung, Yu-Cheng Chen, Juan-Cheng Yang, Yang-Chang Wu, Mei-Chin Lu   +11 more
doaj   +1 more source

Topoisomerase-Mediated DNA Damage in Neurological Disorders

Frontiers in Aging Neuroscience, 2021
The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders.
Morgan Crewe, Ram Madabhushi
doaj   +1 more source

Resveratrol Modulates the Topoisomerase Inhibitory Potential of Doxorubicin in Human Colon Carcinoma Cells

Molecules, 2014
Resveratrol (RSV) is currently being widely discussed as potentially useful for anticancer therapy in combination with classical chemotherapeutics, e.g., the topoisomerase II (TOP II) poison doxorubicin (DOX).
Anika Schroeter, Doris Marko
doaj   +1 more source