RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals [PDF]
, 2016 DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain.
Ahmad, Muzammil +20 more
core +3 more sources
Anti-topoisomerase drugs as potent inducers of chromosomal aberrations
Genetics and Molecular Biology, 2000 DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs.
Loredana Bassi, Fabrizio Palitti
doaj +1 more source
Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases [PDF]
, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Berrido, Andrea +5 more
core +1 more source
eLife, 2022 Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong +4 more
doaj +1 more source
Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]
, 2015 We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth +12 more
core +2 more sources
DNA topoisomerases in mtDNA maintenance and ageing.
Experimental Gerontology, 2014 DNA topoisomerases pass DNA strands through each other, a function essential for all DNA metabolic processes that create supercoils or entanglements of DNA. Topoisomerases play an ambivalent role in nuclear genome maintenance: Deficiency compromises gene
S. Sobek, F. Boege
semanticscholar +1 more source
DNA topoisomerase inhibitors: biflavonoids from Ouratea species
Brazilian Journal of Medical and Biological Research, 2002 Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg +6 more
doaj +1 more source
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi +34 more
core +1 more source
An Experimental Framework to Examine the Influence of Promoter Architecture and Genomic Context on Gene Expression [PDF]
, 2020 Transcription is a fundamental process of gene expression. Information stored in DNA is transcribed into different types of mobile RNA, which play a role in various essential processes of the cell, e.g. translation.
Klein, Carlo Anton
core +1 more source
Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]
, 2016 DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C +4 more
core +1 more source