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Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life
CellsTopoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
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eLife, 2022 Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by 12 tandem (HhH)2 domains, which include 3 AP lyase repair domains.
Amy Osterman, Alfonso Mondragón
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Cell Reports, 2016 During transcription and DNA replication, the DNA template is overwound ahead of RNA and DNA polymerases and relaxed by DNA topoisomerases. Inhibitors of topoisomerases are potent anti-cancer agents.
Cyril Ribeyre +6 more
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PLoS Genetics, 2012 To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings.
Jakob Madsen Pedersen +9 more
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Antibiotics, 2023 Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibacterial agents that target bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Our recently disclosed crystal structure of an NBTI ligand in complex with DNA gyrase
Maja Kokot +5 more
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Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.
PLoS ONE, 2010 BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts +4 more
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Mechanism of Type IA Topoisomerases
Molecules, 2020 Topoisomerases in the type IA subfamily can catalyze change in topology for both DNA and RNA substrates. A type IA topoisomerase may have been present in a last universal common ancestor (LUCA) with an RNA genome.
Tumpa Dasgupta +2 more
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55.2, a phage T4 ORFan gene, encodes an inhibitor of Escherichia coli topoisomerase I and increases phage fitness. [PDF]
PLoS ONE, 2015 Topoisomerases are enzymes that alter the topological properties of DNA. Phage T4 encodes its own topoisomerase but it can also utilize host-encoded topoisomerases. Here we characterized 55.2, a phage T4 predicted ORF of unknown function.
Yves Mattenberger +2 more
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Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer
Антибиотики и Химиотерапия, 2020 Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an ...
A. A. Samuseva +3 more
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Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Cancer is a major health issue adsorbing the attention of a biomedical research. To fight this disease, new drugs are developed, specifically tailored to target biological pathways or peculiar components of the tumour cells.
Valeria Visone +5 more
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