Results 11 to 20 of about 2,307,592 (280)

DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.

PLoS Genetics, 2012
To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings.
Jakob Madsen Pedersen, Jacob Fredsoe, Morten Roedgaard, Lotte Andreasen, Kamilla Mundbjerg, Mogens Kruhøffer, Marie Brinch, Mikkel Heide Schierup, Lotte Bjergbaek, Anni Hangaard Andersen   +9 more
doaj   +2 more sources

The Dynamic Interplay Between DNA Topoisomerases and DNA Topology. [PDF]

Biophys Rev, 2016
Seol Y, Neuman KC.
europepmc   +3 more sources

Supercoiled DNA recognition and cleavage control in topoisomerase VI [PDF]

Nature Communications
Type II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively ...
Daniel E. Richman, Timothy J. Wendorff, Fahad Rashid, Curtis Beck, Qianyun Yan, Haley R. Johnson, Ryan A. Eckerty, Jonathan M. Fogg, Matthew L. Baker, Lynn Zechiedrich, James M. Berger   +10 more
doaj   +2 more sources

Topoisomerases as Targets for Novel Drug Discovery [PDF]

Pharmaceuticals
DNA topoisomerases (topo) are essential enzymes that maintain the integrity of the genome by regulating the topological state of DNA during replication, transcription, recombination and repair [...]
Andrej Perdih
doaj   +2 more sources

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate [PDF]

Nature Communications, 2018
Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-
Shin-Fu Chen, Nan-Lan Huang, Jung-Hsin Lin, Chyuan-Chuan Wu, Ying-Ren Wang, Yu-Jen Yu, Michael K. Gilson, Nei-Li Chan   +7 more
doaj   +3 more sources

Targeting DNA topoisomerases: past & future. [PDF]

Cancer Drug Resist, 2021
Gmeiner WH, van Waardenburg RCAM.
europepmc   +4 more sources

DNA binding and cleavage mechanism of DNA topoisomerase VI, an evolutionary counterpart of Spo11/Wadjet/Gabija systems [PDF]

Structural Dynamics
Type II topoisomerases resolve DNA supercoiling and chromosome entanglements. Type IIB topoisomerases, exemplified by Top6, are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 subunits ...
Daniel E Richman, Timothy J Wendorff, Fahad Rashid, Curtis Beck, Matthew L Baker, Jonathan M Fogg, Lynn Zechiedrich, James M Berger   +7 more
doaj   +2 more sources

A T5 Exonuclease-Based Assay for DNA Topoisomerases and DNA Intercalators [PDF]

ACS Omega, 2021
Zifang Deng, Fenfei Leng
doaj   +2 more sources

DNA Topoisomerases

Methods in Molecular Biology, 2018
M. Drolet
openaire   +2 more sources

Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases. [PDF]

Proc Natl Acad Sci U S A, 2013
Lee SH, Siaw GE, Willcox S, Griffith JD, Hsieh TS.   +4 more
europepmc   +2 more sources