Results 11 to 20 of about 14,206 (239)
Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Cancer is a major health issue adsorbing the attention of a biomedical research. To fight this disease, new drugs are developed, specifically tailored to target biological pathways or peculiar components of the tumour cells.
Valeria Visone +5 more
doaj +2 more sources
Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching. [PDF]
ACS Omega, 2019 DNA topoisomerases are essential enzymes for all living organisms and important targets for anticancer drugs and antibiotics. Although DNA topoisomerases have been studied extensively, steady-state kinetics has not been systematically investigated ...
Wang Y +7 more
europepmc +4 more sources
What's on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases. [PDF]
Int J Mol Sci, 2023 DNA topoisomerases have an essential role in resolving topological problems that arise due to the double-helical structure of DNA. They can recognise DNA topology and catalyse diverse topological reactions by cutting and re-joining DNA ends.
Vidmar V, Vayssières M, Lamour V.
europepmc +2 more sources
Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase. [PDF]
PLoS Genetics, 2017 Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind
Wareed Ahmed +5 more
doaj +1 more source
Structural study of Topoisomerase IV-DNA-Levofloxacin complexes from Streptococcus pneumoniae [PDF]
E3S Web of Conferences, 2019 S. pneumoniae is an important pathogen causing pulmonary infection, acute otitis media and purulent meningitis in infants and children. Type II topoisomerases are enzymes that play essential roles in DNA replication, chromosome segregation and ...
Wang Xilan
doaj +1 more source
Molecular Docking for the Development of Alternative Therapies against Leishmaniasis
Chemistry Proceedings, 2023 Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata +3 more
doaj +1 more source
Journal of Nanobiotechnology, 2021 Most activity-based molecular probes are designed to target enzymes that catalyze the breaking of chemical bonds and the conversion of a unimolecular substrate into bimolecular products.
Sai Ba +3 more
doaj +1 more source
SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases
Frontiers in Molecular Biosciences, 2022 Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA structures arising in double-stranded DNA.
Yilun Sun, John L. Nitiss, Yves Pommier
doaj +1 more source
Controlling the topology of mammalian mitochondrial DNA
Open Biology, 2021 The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes called nucleoids, and the density of mtDNA packaging affects mitochondrial gene ...
Katja E. Menger +3 more
doaj +1 more source
Topological Process of Splitting DNA-Links
Biomath, 2022 A DNA replicon is modeled by a special type of 2-component link, called a DNA-link, in which two circles form a double helix around a trivial center core curve.
Abdul Adheem Mohamad, Tsukasa Yashiro
doaj +1 more source