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A Review of Natural and Synthetic Chalcones as Anticancer Agents Targeting Topoisomerase Enzymes [PDF]
MoleculesCancer remains one of the leading causes of morbidity and mortality worldwide, driving the search for innovative and selective therapeutic agents. Topoisomerases I and II are essential enzymes involved in key cellular processes such as DNA replication ...
François-Xavier Toublet +2 more
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Topoisomerases as Targets for Novel Drug Discovery [PDF]
PharmaceuticalsDNA topoisomerases (topo) are essential enzymes that maintain the integrity of the genome by regulating the topological state of DNA during replication, transcription, recombination and repair [...]
Andrej Perdih
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DNA topoisomerases as molecular targets for anticancer drugs
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells ...
Kamila Buzun +3 more
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Supercoiled DNA recognition and cleavage control in topoisomerase VI [PDF]
Nature CommunicationsType II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively ...
Daniel E. Richman +10 more
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DNA binding and cleavage mechanism of DNA topoisomerase VI, an evolutionary counterpart of Spo11/Wadjet/Gabija systems [PDF]
Structural DynamicsType II topoisomerases resolve DNA supercoiling and chromosome entanglements. Type IIB topoisomerases, exemplified by Top6, are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 subunits ...
Daniel E Richman +7 more
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New Insights into the Geometry and Topology of DNA Replication Intermediates [PDF]
BiologyThe regulation of superhelical stress, mediated by the combined action of topoisomerases and fork rotation, is crucial for DNA replication. The conformational changes during DNA replication are still experimentally challenging, mainly due to the rapid ...
Victor Martínez +7 more
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Biology, 2021 DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined.
Jorge Cebrián +5 more
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mSystems, 2021 Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases.
Martyna Gongerowska-Jac +8 more
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Dual Targeting Topoisomerase/G-Quadruplex Agents in Cancer Therapy—An Overview
Biomedicines, 2022 Topoisomerase (Topo) inhibitors have long been known as clinically effective drugs, while G-quadruplex (G4)-targeting compounds are emerging as a promising new strategy to target tumor cells and could support personalized treatment approaches in the near
Silvia Salerno +5 more
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Current Protocols in Pharmacology, 2012 AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and pass double‐stranded DNA. DNA topoisomerases are important targets
John L, Nitiss +4 more
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