Results 1 to 10 of about 16,235 (248)

DNA topoisomerases as molecular targets for anticancer drugs

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells ...
Anna Bielawska, Agnieszka Gornowicz, Kamila Buzun   +2 more
exaly   +3 more sources

Topoisomerases as Targets for Novel Drug Discovery [PDF]

Pharmaceuticals
DNA topoisomerases (topo) are essential enzymes that maintain the integrity of the genome by regulating the topological state of DNA during replication, transcription, recombination and repair [...]
Andrej Perdih
doaj   +3 more sources

Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks [PDF]

Nature Communications
Resolving complex topological structures at replication forks is essential for faithful DNA replication, yet the underlying mechanisms remain poorly understood.
Mégane Da Mota, Axel Delamarre, Antoine Barthe, Jessica Jackson, Nail Bouzalmad, Alba Torán-Vilarrubias, Yea-Lih Lin, Cyril Ribeyre, Alessandro Vindigni, Philippe Pasero, Armelle Lengronne   +10 more
doaj   +2 more sources

Supercoiled DNA recognition and cleavage control in topoisomerase VI [PDF]

Nature Communications
Type II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively ...
Daniel E. Richman, Timothy J. Wendorff, Fahad Rashid, Curtis Beck, Qianyun Yan, Haley R. Johnson, Ryan A. Eckerty, Jonathan M. Fogg, Matthew L. Baker, Lynn Zechiedrich, James M. Berger   +10 more
doaj   +2 more sources

DNA binding and cleavage mechanism of DNA topoisomerase VI, an evolutionary counterpart of Spo11/Wadjet/Gabija systems [PDF]

Structural Dynamics
Type II topoisomerases resolve DNA supercoiling and chromosome entanglements. Type IIB topoisomerases, exemplified by Top6, are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 subunits ...
Daniel E Richman, Timothy J Wendorff, Fahad Rashid, Curtis Beck, Matthew L Baker, Jonathan M Fogg, Lynn Zechiedrich, James M Berger   +7 more
doaj   +2 more sources

Two-Dimensional Gel Electrophoresis to Study the Activity of Type IIA Topoisomerases on Plasmid Replication Intermediates

Biology, 2021
DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined.
Jorge Cebrián, Victor Martínez, Pablo Hernández, Dora B. Krimer, María-José Fernández-Nestosa, Jorge B. Schvartzman   +5 more
doaj   +1 more source

Global Chromosome Topology and the Two-Component Systems in Concerted Manner Regulate Transcription in Streptomyces

mSystems, 2021
Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases.
Martyna Gongerowska-Jac, Marcin J. Szafran, Jakub Mikołajczyk, Justyna Szymczak, Magdalena Bartyńska, Anna Gierlikowska, Sylwia Biały, Marie A. Elliot, Dagmara Jakimowicz   +8 more
doaj   +1 more source

Dual Targeting Topoisomerase/G-Quadruplex Agents in Cancer Therapy—An Overview

Biomedicines, 2022
Topoisomerase (Topo) inhibitors have long been known as clinically effective drugs, while G-quadruplex (G4)-targeting compounds are emerging as a promising new strategy to target tumor cells and could support personalized treatment approaches in the near
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Sabrina Taliani, Federico Da Settimo   +5 more
doaj   +1 more source

DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation. [PDF]

PLoS ONE, 2015
To investigate the importance of topoisomerases for transcription of the galactose induced genes, we have studied the expression of GAL1, GAL2, GAL7 and GAL10 in Saccharomyces cerevisiae cells deficient for topoisomerases I and II.
Morten Roedgaard, Jacob Fredsoe, Jakob Madsen Pedersen, Lotte Bjergbaek, Anni Hangaard Andersen   +4 more
doaj   +1 more source

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase. [PDF]

PLoS Genetics, 2017
Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind
Wareed Ahmed, Claudia Sala, Shubhada R Hegde, Rajiv Kumar Jha, Stewart T Cole, Valakunja Nagaraja   +5 more
doaj   +1 more source