Results 11 to 20 of about 23,598 (268)

Our Evolving Understanding of the Mechanism of Quinolones [PDF]

Antibiotics, 2018
The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez, Jonathan M. Stokes, Ivan Matic   +2 more
doaj   +3 more sources

DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation. [PDF]

PLoS ONE, 2015
To investigate the importance of topoisomerases for transcription of the galactose induced genes, we have studied the expression of GAL1, GAL2, GAL7 and GAL10 in Saccharomyces cerevisiae cells deficient for topoisomerases I and II.
Morten Roedgaard, Jacob Fredsoe, Jakob Madsen Pedersen, Lotte Bjergbaek, Anni Hangaard Andersen   +4 more
doaj   +1 more source

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase. [PDF]

PLoS Genetics, 2017
Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind
Wareed Ahmed, Claudia Sala, Shubhada R Hegde, Rajiv Kumar Jha, Stewart T Cole, Valakunja Nagaraja   +5 more
doaj   +1 more source

Women’s contribution in understanding how topoisomerases, supercoiling, and transcription control genome organization

Frontiers in Molecular Biosciences, 2023
One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while the nucleus containing it is almost one million times smaller.
Laura Martin, Maria Victoria Neguembor, Maria Victoria Neguembor, Maria Pia Cosma, Maria Pia Cosma, Maria Pia Cosma, Maria Pia Cosma, Maria Pia Cosma   +7 more
doaj   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly, A Hellman, A Helmrich, AA Burrow, AJ Swerdlow, AT Jonstrup, AY Chen, BH Long, C Pondarré, CH Cheng, Christine E. Lehman, CM Caudill, D Mishmar, D Vane, DJ Mulvihill, E Grabczyk, E Zlotorynski, F de Vathaire, F Pelliccia, FH Drake, FM Bar, G Abdurashidova, G Capranico, GR Bignell, GR Sutherland, H Zhang, HY Wu, I Bongarzone, J Sambrook, JC Wang, JM Allan, JM Fortune, K Reddy, K Takeuchi, KR Hande, KW Gow, L Enewold, L Postow, Laura W. Dillon, LB Travis, Le Beau, Levi C. T. Pierce, LF Liu, LW Dillon, LW Dillon, M Drolet, M Gandhi, M Zuker, MB Smith, MD Been, MD Been, MF Arlt, MN Nikiforova, MS Kim, NR Lemoine, O Handt, P Boffetta, PA Smanik, R Garcia-Carbonero, R Venkitaraman, RT Hay, S Anderson, S Corbin, S Klugbauer, S McAvoy, S Tuduri, S Wada, SG Durkin, SG Durkin, SJ Froelich-Ammon, SM Jhiang, SM Vos, SN Shah, T Kohno, T Kondo, T Syrovets, TW Glover, TW Glover, Valentin V Rybenkov, X Li, Y Lin, Y Lin, YE Nikiforov, YE Nikiforov, YE Nikiforov, Yuh-Hwa Wang, Yuri E. Nikiforov   +86 more
core   +5 more sources

Updated Review on Clinically-Relevant Properties of Delafloxacin

Antibiotics, 2023
The extensive use of fluoroquinolones has been consequently accompanied by the emergence of bacterial resistance, which triggers the necessity to discover new compounds.
Adrien Turban, François Guérin, Aurélien Dinh, Vincent Cattoir   +3 more
doaj   +1 more source

DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.

PLoS Genetics, 2012
To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings.
Jakob Madsen Pedersen, Jacob Fredsoe, Morten Roedgaard, Lotte Andreasen, Kamilla Mundbjerg, Mogens Kruhøffer, Marie Brinch, Mikkel Heide Schierup, Lotte Bjergbaek, Anni Hangaard Andersen   +9 more
doaj   +1 more source

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

eLife, 2020
Topoisomerase II (TOP2) relieves topological stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently linked TOP2 DNA-protein intermediate, termed TOP2 cleavage complex (TOP2cc).
Nicholas Sciascia, Wei Wu, Dali Zong, Yilun Sun, Nancy Wong, Sam John, Darawalee Wangsa, Thomas Ried, Samuel F Bunting, Yves Pommier, André Nussenzweig   +10 more
doaj   +1 more source

Controlling the topology of mammalian mitochondrial DNA

Open Biology, 2021
The genome of mitochondria, called mtDNA, is a small circular DNA molecule present at thousands of copies per human cell. MtDNA is packaged into nucleoprotein complexes called nucleoids, and the density of mtDNA packaging affects mitochondrial gene ...
Katja E. Menger, Alejandro Rodríguez-Luis, James Chapman, Thomas J. Nicholls   +3 more
doaj   +1 more source

Bacterial Topoisomerases, Anti‐Topoisomerases, and Anti‐Topoisomerase Resistance [PDF]

Clinical Infectious Diseases, 1998
Topoisomerases are ubiquitous enzymes necessary for controlling the interlinking and twisting of DNA molecules. Among the four topoisomerases identified in eubacteria, two, DNA gyrase and topoisomerase IV have been exploited by nature and the pharmaceutical industry as antibacterial targets.
openaire   +2 more sources