Results 31 to 40 of about 16,235 (248)

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Fisher, LM, Dias, M, PAN X. S, Pan, XS, Palumbo, M, DIAS M, FISHER L. M., PALUMBO, MANLIO   +7 more
core   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

AS1041, a Novel Synthesized Derivative of Marine Natural Compound Aspergiolide A, Arrests Cell Cycle, Induces Apoptosis, and Inhibits ERK Activation in K562 Cells

Marine Drugs, 2017
AS1041 is a novel synthesized anthraquinone lactone derivative of marine natural compound aspergiolide A (ASP-A) with new structure skeleton and marked cytotoxicity in cancer cells.
Fengli Yuan, Liang Qiao, Yinghan Chen, Xin Qi, Yankai Liu, Dehai Li, Qianqun Gu, Jing Li, Ming Liu   +8 more
doaj   +1 more source

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Pharmaceuticals, 2023
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie   +2 more
doaj   +1 more source

Structural study of Topoisomerase IV-DNA-Levofloxacin complexes from Streptococcus pneumoniae [PDF]

E3S Web of Conferences, 2019
S. pneumoniae is an important pathogen causing pulmonary infection, acute otitis media and purulent meningitis in infants and children. Type II topoisomerases are enzymes that play essential roles in DNA replication, chromosome segregation and ...
Wang Xilan
doaj   +1 more source

On the viability of Escherichia coli cells lacking DNA topoisomerase I [PDF]

, 2012
Copyright @ 2012 Stockum et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution,
Lloyd, RG, Lloyd Robert G, Rudolph Christian J, Stockum Anna, Christian J Rudolph, Stockum, A, Anna Stockum, Robert G Lloyd, Rudolph, CJ   +8 more
core   +1 more source

Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes

, 2023
Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism.
Hunter Davis, Xiaohua Jiang, William Carroll, Joseph E. Deweese, Lauren A. Fielding, Edward C. Lisic   +5 more
core   +1 more source

Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching [PDF]

, 2019
DNA topoisomerases are essential enzymes for all living organisms and important targets for anticancer drugs and antibiotics. Although DNA topoisomerases have been studied extensively, steady-state kinetics has not been systematically investigated ...
Leng, Fenfei, Wang, Yunke, Tse-Dinh, Yuk-Ching, Rakela, Samantha, Hua, Zi-Chun, Nitiss, John L, Chambers, Jeremy W, Muller, Mark T   +7 more
core   +2 more sources

Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds

Pharmaceuticals, 2023
With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary.
Josephine Geertsen Keller, Kamilla Vandsø Petersen, Karol Mizielinski, Celine Thiesen, Lotte Bjergbæk, Rosa M. Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Angela Trejo, Carme Masdeu, Concepcion Alonso, Birgitta R. Knudsen, Cinzia Tesauro   +12 more
doaj   +1 more source

Our Evolving Understanding of the Mechanism of Quinolones

Antibiotics, 2018
The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez, Jonathan M. Stokes, Ivan Matic   +2 more
doaj   +1 more source